| Laser-induced fluorescence detection of atherosclerotic plaque with hematoporphyrin derivative used as an exogenous probe. | |
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MedLine Citation:
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PMID: 2965255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical use of laser angioplasty is limited by the lack of an adequate guidance system. As a first step toward developing a reliable guidance system, laser-induced surface fluorescence and a fluorescent probe were used to differentiate plaque from normal arterial wall. The aortas from four normal New Zealand white rabbits and six atherosclerotic rabbits were studied in vitro. Rabbits from each group received 2.5 mg/kg of hematoporphyrin derivative intravenously 24 hours before death. Segments of the aortas were irradiated with a helium-cadmium laser, and the tissue surface fluorescence spectra were recorded with an optical multichannel analyzer. A plaque index, based on the resulting spectra, was calculated for each specimen of aorta. The spectra from normal aorta without hematoporphyrin derivative, normal aorta with hematoporphyrin derivative, and from plaque of atherosclerotic rabbits without hematoporphyrin derivative showed the same wavelength dependence. The plaque index values were not significantly different from one another. However, in plaque from atherosclerotic rabbits given hematoporphyrin derivative, the spectrum was markedly different, showing a broad spectral peak at 632 nm. This spectral peak corresponds to the spectral peak of hematoporphyrin derivative and was only seen in the plaque of atherosclerotic rabbits given hematoporphyrin derivative. The plaque index for these specimens was significantly different from all other specimens (p less than 0.001). This difference in fluorescence spectra and plaque index could be incorporated into a guidance system for laser angioplasty. |
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Authors:
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L G Prevosti; J J Wynne; C G Becker; R Linsker; G T Shires |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of vascular surgery Volume: 7 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-05-06 Completed Date: 1988-05-06 Revised Date: 2012-10-03 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 500-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, New York Hospital, Cornell Medical Center, New York City. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon
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methods* Animals Arteriosclerosis / therapy* Fluorescence Fluorescent Dyes Hematoporphyrin Derivative Hematoporphyrins / diagnostic use* Laser Therapy / methods* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes; 0/Hematoporphyrins; 68335-15-9/Hematoporphyrin Derivative |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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