Document Detail

Laser-assisted nasal decolonization of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus.
MedLine Citation:
PMID:  22503099     Owner:  NLM     Status:  Publisher    
OBJECTIVES: Methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S aureus (MRSA) contribute to 25% of nosocomial infections, increasing complications, health care cost, and growing antibiotic resistance. Nasal decolonization (ND) can reduce the staphylococcal infection rate. A new method of laser therapy (LT) MRSA ND was tested. STUDY DESIGN: This is a prospective, nonrandomized study. METHODS: Following institutional review board approvals, 25 patients colonized with MSSA/MRSA were allocated to 4 treatment arms; low-power, dual-wavelength 870-/930-nm laser alone (GR1); low-power, dual-wavelength laser followed by erythromycin (E-mycin) cream (GR2); low-power, dual-wavelength laser followed by peroxide irrigation (GR3); and high-power 940-nm laser alone (GR4). Quantitative cultures were obtained before and after in all arms. Laser therapy was performed via a laser fiber diffuser, delivering 200 to 600 J/cm² to each naris circumferentially. Patient's distribution was 3 in GR1, 14 in GR2, 4 in GR3, and 4 in GR4 (last 10 recruited to GR4). RESULTS: Nasal decolonization for GR1, GR2, GR3, and GR4 was 1 of 3, 13 of 14, 2 of 4, and 4 of 4, respectively. Because LT + E-mycin cleared all first 3 patients of MRSA and MSSA, all remaining patients were treated with LT + Er with over 90% of patients clearing. No adverse events or discomfort were reported. CONCLUSIONS: First human study using LT and topical E-mycin in ND is presented. Laser therapy can eradicate MRSA and potentially resensitization of bacteria to the antimicrobial effect of erythromycin. Although decolonization was maintained at 4 weeks posttreatment, further studies can determine the LT long-term effect.
Yosef P Krespi; Victor Kizhner
Related Documents :
6102939 - An open comparison between free and a fixed combination of diuretic and beta-blocker in...
8590529 - Inotropic therapy for the failing myocardium.
10051289 - Addition of angiotensin ii receptor blockade to maximal angiotensin-converting enzyme i...
7648219 - Relative benefits of different antihypertensive drugs in the prevention of vascular com...
11009269 - Containment of heart failure hospitalizations and cost by angiotensin-converting enzyme...
2826549 - A 52-week comparison of lisinopril, hydrochlorothiazide, and their combination in hyper...
15673859 - Optimal timing of acustimulation for antiemetic prophylaxis as an adjunct to ondansetro...
23212859 - Effect of timing of dialysis commencement on clinical outcomes of patients with planned...
9475029 - Primary argon laser trabeculoplasty vs pilocarpine 2% in primary open angle glaucoma: t...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-12
Journal Detail:
Title:  American journal of otolaryngology     Volume:  -     ISSN:  1532-818X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Lennox Hill Hospital, New York, NY, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation of the influence of homopolymerization on the removal of water-insoluble organics by graf...
Next Document:  Staufen1-Mediated mRNA Decay Functions in Adipogenesis.