Document Detail

Laser Doppler flowmetry, transcutaneous oxygen pressure and thermal clearance in patients with vascular intermittent claudication.
MedLine Citation:
PMID:  8500976     Owner:  NLM     Status:  MEDLINE    
In the present study, heat thermal clearance (HTC) was compared to laser Doppler flowmetry (LDF) and transcutaneous oxygen pressure (tcPO2), measured on the forefoot of 17 patients with vascular intermittent claudication and 10 controls in various positions at rest and after a treadmill exercise test. The mean ankle brachial systolic pressure ratio (ABSP) of the patients, measured using ultrasonic Doppler velocimetry, was 0.53 +/- 0.05. Their walking distance was 480 +/- 100 meters, the treadmill exercise being stopped as soon as pain sensation. No statistically significant difference was found between patients and controls for HTC, LDF, tc P02, forefoot and ankle skin temperatures. Statistically significant differences between patients and controls occurred in the sitting position for tcPO2, in standing position for HTC and after treadmill exercise for tcPO2 and LDF. When assuming the sitting position HTC did not vary significantly in patients and decreased in controls, LDF decreased and tcPO2 increased in both groups. After treadmill exercise, HTC in patients did not vary compared to supine values and HTC decreased in controls, tcPO2 remained unchanged in controls and decreased in patients, LDF increased in controls and decreased in patients. No significant correlations were found between the different techniques measured at rest in patients and controls. However in patients, after the treadmill test, LDF correlated with the walking distance (r = 0.667) and with ABSP (r = 0.641), HTC inversely correlated with the walking distance (r = -0.680) and ABSP (r = -0.577). Laser Doppler, tcPO2 and HTC are useful as tools to understand the alterations of cutaneous microcirculation of the lower limbs in patients with V.I.C.. However their results need to be interpreted with caution because these methods do not measure directly blood flow.
J L Saumet; R Fabry; P Girard; M Saumet; P Abraham; G Schaff
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation     Volume:  12     ISSN:  0167-6865     ISO Abbreviation:  Int J Microcirc Clin Exp     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-30     Completed Date:  1993-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8400122     Medline TA:  Int J Microcirc Clin Exp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  173-83     Citation Subset:  IM    
Laboratoire de Physiologie et d'Explorations vasculaires, C.H.R.U., Angers, France.
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MeSH Terms
Blood Gas Monitoring, Transcutaneous*
Blood Pressure
Exercise Test
Foot / blood supply
Intermittent Claudication / physiopathology*
Laser-Doppler Flowmetry*
Middle Aged
Regional Blood Flow
Skin / blood supply*,  ultrasonography
Skin Temperature*
Thermal Conductivity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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