Document Detail


Laser Doppler flowmetry assessment of peristernal perfusion after cardiac surgery: beneficial effect of negative pressure therapy.
MedLine Citation:
PMID:  21167000     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Negative pressure therapy has been successfully applied to clean, closed incisions in patients at high-risk for wound complications. Using laser Doppler flowmetry, we evaluated peristernal perfusion after cardiac surgery via median sternotomy, assessing the influence of mammary artery harvesting and the impact of negative pressure therapy. Twenty adult patients underwent median sternotomy for cardiac surgery followed by routine closure. Negative pressure was applied at 125 mm Hg for 4 days postoperatively in patients with increased risk for wound complications (n = 10, negative pressure group); standard dressings were applied to control incisions postoperatively (n = 10). Presternal perfusion was determined at baseline and daily for 4 days postoperatively using laser Doppler flowmetry. Results within and between groups were compared with analysis of variance. No wound complications were encountered in either group. Perfusion increased among the patients who underwent negative pressure therapy and decreased among the controls (P = 0·004). Mammary artery harvesting reduced peristernal perfusion by 25·7% in the controls, but negative pressure increased perfusion by 100% after mammary harvesting (P = 0·04). Negative pressure therapy increased perfusion relative to controls and compensated for reduced perfusion rendered by mammary artery harvesting, providing additional support for 'well wound therapy' in high-risk patients.
Authors:
Broadus Zane Atkins; Jean K Tetterton; Rebecca P Petersen; Kista Hurley; Walter G Wolfe
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-17
Journal Detail:
Title:  International wound journal     Volume:  8     ISSN:  1742-481X     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230907     Medline TA:  Int Wound J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  56-62     Citation Subset:  -    
Copyright Information:
© 2010 The Authors. © 2010 No claim to original US government works.
Affiliation:
B Zane Atkins, MD, Department of Surgery, Durham VA Medical Center, Durham, NC, USA, Department of Surgery, Uniformed Services University of Health Sciences, Bethesda, MD, USA JK Tetterton, NP, Department of Surgery, Durham VA Medical Center, Durham, NC, USA, Department of Surgery, Duke University Medical Center, Durham, NC, USA RP Petersen, MD, MSc, Department of Surgery, University of Washington School of Medicine Seattle, Seattle, WA, USA K Hurley PA-C, Department of Surgery, Durham VA Medical Center, Durham, NC, USA WG Wolfe, MD, Department of Surgery, Durham VA Medical Center, Durham, NC, USA, Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low tempe...
Next Document:  Variants in genes involved in functional pathways associated with hypertension in African Americans.