| Laser Doppler flowmetry of hepatic microcirculation during Pringle's maneuver: determination of spatial and temporal liver tissue perfusion heterogeneity. | |
| | |
MedLine Citation:
|
PMID: 20215755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Laser Doppler flowmetry (LDF) is frequently used for non-invasive microvascular perfusion measurements. The aim of the present study was to analyze liver blood flow heterogeneity in detail using LDF devices under normal and low-flow conditions. MATERIALS AND METHODS: In 5 anesthetized and laparotomized Suabian-Hall strain pigs, systemic hemodynamics and hepatic arterial/portal venous blood flow were constantly recorded. Hepatic microcirculation was assessed by 2 different LDF devices, analyzing microvascular flow and velocity before, during and after inducing a Pringle's maneuver for hepatic inflow occlusion. Offline data analysis comprised differentiation between the two LDF devices used as well as calculation of temporal and spatial heterogeneity of liver perfusion. RESULTS: Pringle's maneuver induced complete inflow occlusion, confirmed by hepatic arterial/portal venous blood flow measurement. Laser Doppler signals showed a significant decrease during Pringle's maneuver. Spatial heterogeneity of flow and velocity increased more than temporal heterogeneity during Pringle's maneuver. CONCLUSION: Both LDF devices proved suitable for assessing hepatic microvascular perfusion during normal perfusion and low-flow conditions. Reduced microvascular perfusion induces a significant increase in temporal and spatial perfusion heterogeneity. In particular, the pronounced spatial heterogeneity requires measurements at different places when assessing hepatic microcirculation by LDF during impaired perfusion conditions. |
| | |
Authors:
|
S Richter; J Sperling; O Kollmar; M D Menger; M K Schilling; |
Related Documents
:
|
17188355 - Pfos levels in the blood and liver of a small insectivorous songbird near a fluorochemi... 6134795 - Determinants of systemic availability of promethazine in rabbits. 9423205 - Spectral analysis applied to hepatobiliary dynamic scintigraphy with 99tcm-n-pyridoxyl-... 355065 - Regulation of blood ammonia. 9869435 - Inflammatory response to cardiopulmonary bypass. 12617775 - Therapeutic effects of interleukin-1 receptor antagonist on allergic rhinitis of guinea... |
Publication Detail:
|
Type: Journal Article Date: 2010-03-09 |
Journal Detail:
|
Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 44 ISSN: 1421-9921 ISO Abbreviation: Eur Surg Res Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-07-29 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 152-8 Citation Subset: IM |
Copyright Information:
|
(c) 2010 S. Karger AG, Basel. |
Affiliation:
|
Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg/Saar, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Hemodynamics Hepatic Artery / physiology, ultrasonography Laser-Doppler Flowmetry Liver / blood supply*, injuries, ultrasonography* Liver Circulation / physiology* Microcirculation / physiology* Models, Animal Portal Vein / physiology, ultrasonography Reperfusion Injury / physiopathology, ultrasonography Sus scrofa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prediction of Discharge Destination after Neurological Rehabilitation in Stroke Patients.
Next Document: A Hypericum Extract in the Treatment of Depressive Symptoms in Outpatients: An Open Study.