Document Detail


Laryngeal muscle activities with cerebral hypoxia-ischemia in newborn lambs.
MedLine Citation:
PMID:  12091176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study tested the hypotheses that (1) acute cerebral hypoxia-ischemia changes laryngeal adductor, laryngeal abductor, and diaphragmatic activities, resulting in central apnea with laryngeal closure; and (2) these laryngeal muscle activities act to maintain absolute lung volume. The respiratory pattern was determined in three asphyxiated, awake preterm lambs after cesarean section birth and in 12 awake, term lambs, with normal lung function, after induction of acute cerebral hypoxia-ischemia by occlusion of the brachiocephalic artery. Electrocorticogram activity, flow, volume, electromyograms of laryngeal abductor and adductor muscles and diaphragm, and, in the term lambs, trans-upper airway pressure and carotid blood flow were recorded. With either preterm birth asphyxia or induced acute cerebral hypoxia-ischemia, minute ventilation initially increased, and then hypopnea occurred. During the hypopnea, laryngeal adductor activity was prominent, accompanied by an increased upper airway pressure and a maintained/raised absolute lung volume. Thus, when acute hypoxia-ischemia limited to the upper body is induced in lambs with normal lung function, expiratory laryngeal adduction with closure of the upper airway occurs and likely functions to aid autoresuscitation.
Authors:
Alastair A Hutchison; David J Burchfield; John A Wozniak; Sondra J Mohrman
Related Documents :
7680496 - Potentiation by hypoxia of contractions caused by angiotensin ii in dog and monkey cere...
7955546 - Interactions between the circulatory effects of central hypovolaemia and arterial hypox...
11930226 - Changes in glycine content in mouse brain during hypoxic preconditioning.
2225896 - High-frequency oscillation during simulated altitude exposure.
23769576 - Catestatin could ameliorate proliferating changes of target organs in spontaneously hyp...
6996616 - Infection of mice by aerosols of klebsiella pneumoniae under hyperbaric conditions.
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  166     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-01     Completed Date:  2002-07-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Kentucky, Lexington 40536-0298, USA. aahutch@msn.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Apnea / physiopathology*
Diaphragm / physiopathology*
Electromyography
Hypoxia-Ischemia, Brain / physiopathology*
Laryngeal Muscles / physiopathology*
Respiratory Mechanics
Sheep
Grant Support
ID/Acronym/Agency:
HL-39858/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Association between air pollution and lung function growth in southern California children: results ...
Next Document:  Altered breathing pattern after prenatal nicotine exposure in the young lamb.