Document Detail

Laryngeal keratosis preceding laryngeal carcinoma. A report of four cases.
MedLine Citation:
PMID:  7092689     Owner:  NLM     Status:  MEDLINE    
Detailed descriptions of the laryngeal mucosal changes that precede squamous cell carcinoma are infrequent. The criteria for identification of epithelial changes that are considered "premalignant" vary widely among pathologists. Presented herein are the histological details and clinical findings of four patients with biopsy-proved laryngeal keratosis in whom laryngeal carcinoma subsequently developed over intervals ranging from ten months to six years. The epithelial changes are variable but generally consist of a thickened mucosa with prominent alterations in the pattern of maturation. These maturation abnormalities range from proliferation of immature "basal-like" cells with little or no surface keratinization (classic form of atypia or dysplasia) to markedly thickened mucosa with prominent keratinization, both on the surface and in individual cells in the deep portions of the mucosa. Multiple recurrence in two of the patients with mucosal thickening and extensive individual cell and surface keratinization suggest that not only this histopathologic change, but the propensity for recurrence, may both be indicators of premalignant epithelial change.
J D Crissman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of otolaryngology (Chicago, Ill. : 1960)     Volume:  108     ISSN:  0003-9977     ISO Abbreviation:  Arch Otolaryngol     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376526     Medline TA:  Arch Otolaryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  445-8     Citation Subset:  AIM; IM    
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MeSH Terms
Carcinoma, Squamous Cell / etiology*
Keratosis / complications*,  pathology
Laryngeal Diseases / complications*,  pathology
Laryngeal Neoplasms / etiology*,  pathology
Larynx / pathology
Middle Aged
Precancerous Conditions*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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