Document Detail

Laryngeal carcinoma after radiation therapy: correlation of abnormal MR imaging signal patterns in laryngeal cartilage with the risk of recurrence.
MedLine Citation:
PMID:  8539369     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To correlate abnormal magnetic resonance (MR) imaging signal patterns in cartilage with the effectiveness of radiation treatment. MATERIALS AND METHODS: Eighty previously untreated patients underwent MR imaging and radiation therapy with a curative intent. Cartilage was considered to have an abnormal signal pattern if it had intermediate signal intensity on T1-weighted spin-echo (SE) MR images and high signal intensity on T2-weighted SE MR images. The minimum follow-up was 2 years. RESULTS: Abnormal MR imaging signal patterns of the thyroid cartilage (P < .001; P < .04) were more ominous than those of other cartilage. Abnormal signal patterns in cartilage of patients with small tumors (< 5 cm3 and especially < 1 cm3) were less significant. Abnormal signal patterns in cartilage combined with a large tumor (> 5 cm3) worsened the prognosis significantly (P < .05). CONCLUSION: Abnormal MR imaging signal patterns in cartilage may not indicate a poor prognosis in every case. Abnormal signal intensity in the thyroid cartilage combined with a tumor volume of > 5 cm3, however, appears to indicate an adverse prognosis with regard to tumor recurrence.
J A Castelijns; M W van den Brekel; H Tobi; E M Smit; R P Golding; C van Schaik; G B Snow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  198     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-06     Completed Date:  1996-02-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  AIM; IM    
Department of Radiology, Vrije Universiteit Hospital, Amsterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / diagnosis*,  radiotherapy*
Laryngeal Cartilages / pathology*
Laryngeal Neoplasms / diagnosis*,  radiotherapy*
Magnetic Resonance Imaging*
Middle Aged
Neoplasm Recurrence, Local
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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