Document Detail


Laryngeal allotransplantation by stages in beagles: an initial study.
MedLine Citation:
PMID:  21911154     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To establish a model of cynolaryngeal transplantation.
METHODS: Ten beagles, matched for weight (8-10 kg) were divided into five groups for allotransplantation. The vascular circulation was managed with an end-to-end or end-to-lateral anastomosis of allograft bilateral common carotid arteries to recipient bilateral common carotid arteries, and bilateral external jugular veins. The recurrent laryngeal nerve was anastomosed end-to-end. Then, a vascularized allograft was embeded in the cervical subcutaneous tissue of the recipient, and cyclosporine administered every day.
RESULTS: The allografts in groups 3, 4, and 5 survived up to 1 month. Groups 1 and 2 showed necrosis and cervical infection.
CONCLUSIONS: Beagles accepted laryngeal allotransplantation by stages (laryngeal allograft fore-embed model). Allograft survival was secluded by glandular organ secretion. Immunosuppression must be continuously administered.
Authors:
Y Jiang; P Dong; N Li; X Li; H Xu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  43     ISSN:  1873-2623     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2733-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Medical College Qingdao University, Shanghai, China.
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