| Laryngeal allotransplantation by stages in beagles: an initial study. | |
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MedLine Citation:
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PMID: 21911154 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To establish a model of cynolaryngeal transplantation. METHODS: Ten beagles, matched for weight (8-10 kg) were divided into five groups for allotransplantation. The vascular circulation was managed with an end-to-end or end-to-lateral anastomosis of allograft bilateral common carotid arteries to recipient bilateral common carotid arteries, and bilateral external jugular veins. The recurrent laryngeal nerve was anastomosed end-to-end. Then, a vascularized allograft was embeded in the cervical subcutaneous tissue of the recipient, and cyclosporine administered every day. RESULTS: The allografts in groups 3, 4, and 5 survived up to 1 month. Groups 1 and 2 showed necrosis and cervical infection. CONCLUSIONS: Beagles accepted laryngeal allotransplantation by stages (laryngeal allograft fore-embed model). Allograft survival was secluded by glandular organ secretion. Immunosuppression must be continuously administered. |
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Authors:
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Y Jiang; P Dong; N Li; X Li; H Xu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 43 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 2733-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Medical College Qingdao University, Shanghai, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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