Document Detail

Larvicidal activity of some secondary lichen metabolites against the mosquito Culiseta longiareolata Macquart (Diptera: Culicidae).
MedLine Citation:
PMID:  21452097     Owner:  NLM     Status:  MEDLINE    
The larvicidal activity of some lichen metabolites, (+)-usnic acid, atranorin, 3-hydroxyphysodic acid and gyrophoric acid, against the second and third instar larvae of the mosquito Culiseta longiareolata were studied. All metabolites caused high larvicidal activities. When metabolites were compared on the basis of their LC(50) values, the order of increasing toxicity was as follows: gyrophoric acid (0.41 ppm) > (+)-usnic acid (0.48 ppm) > atranorin (0.52 ppm) > 3-hydroxyphysodic acid (0.97 ppm). However, when LC(90) values were compared, the order of toxicity was (+)-usnic acid (1.54 ppm) > gyrophoric acid (1.93 ppm) > 3-hydroxyphysodic acid (4.33 ppm) > atranorin (5.63 ppm). In conclusion, our results found that lichen secondary metabolites may have a promising role as potential larvicides.
H Cetin; O Tufan-Cetin; A O Turk; T Tay; M Candan; A Yanikoglu; H Sumbul
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-07-07
Journal Detail:
Title:  Natural product research     Volume:  26     ISSN:  1478-6427     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-07     Completed Date:  2012-08-10     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  350-5     Citation Subset:  IM    
Department of Biology, Faculty of Arts and Science, Akdeniz University, Antalya, Turkey.
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MeSH Terms
Benzofurans / pharmacology
Benzoic Acids / pharmacology
Culicidae / drug effects*
Dibenzoxepins / pharmacology
Hydroxybenzoic Acids / pharmacology
Insecticides / chemistry,  pharmacology*
Larva / drug effects
Lethal Dose 50
Lichens / chemistry*,  metabolism
Molecular Structure
Reg. No./Substance:
0/3-hydroxyphysodic acid; 0/Benzofurans; 0/Benzoic Acids; 0/Dibenzoxepins; 0/Hydroxybenzoic Acids; 0/Insecticides; 125-46-2/usnic acid; 479-20-9/atranorin; 548-89-0/gyrophoric acid

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