Document Detail

Sjögren-Larsson syndrome: delta 5-and delta 6-fatty acid desaturases in skin fibroblasts.
MedLine Citation:
PMID:  3974899     Owner:  NLM     Status:  MEDLINE    
Cultured skin fibroblasts from two patients with Sjögren-Larsson syndrome (SLS) and from a normal control were analyzed for trienoic and tetraenoic fatty acids. In addition, we assayed desaturation of [1-14C]linoleic acid in cells from four patients and four controls. There was no significant effect of the disease on the composition of polyunsaturated fatty acids or on the rate of linoleic acid desaturation in fibroblasts. The results indicate the presence of delta 5- and delta 6-fatty acid desaturases in cells from SLS patients.
J Avigan; B D Campbell; D A Yost; O Hernell; G Holmgren; S F Jagell
Related Documents :
1906979 - Inhibition of arachidonate biosynthesis in hepatoma tissue culture cells by 11-deoxycor...
7733039 - Plasma cholesterol-predictive equations demonstrate that stearic acid is neutral and mo...
3032669 - A major metabolite of delta 1-tetrahydrocannabinol reduces its cataleptic effect in mice.
131119 - Lysine catabolism in rhizoctonia leguminicola and related fungi.
2877879 - Reconstitution of cf1-depleted thylakoid membranes with complete and fragmented chlorop...
2171159 - Beneficial effects of zinc supplementation during chelation treatment of lead intoxicat...
1026559 - Isolation and identification of paracetamol metabolites.
20739419 - Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: ra...
19650639 - Protease inhibitors from a water bloom of the cyanobacterium microcystis aeruginosa.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  35     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-10     Completed Date:  1985-04-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-3     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Fatty Acid Desaturases / metabolism*
Fibroblasts / enzymology
Ichthyosis / enzymology*,  pathology
Linoleoyl-CoA Desaturase
Middle Aged
Skin / enzymology*,  pathology
Reg. No./Substance:
EC 1.14.19.-/Fatty Acid Desaturases; EC Desaturase; EC 1.14.99.-/delta-5 fatty acid desaturase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Brainstem gliomas of childhood: magnetic resonance imaging.
Next Document:  Cerebral vasculitis and hemorrhage associated with phenylpropanolamine.