Document Detail


Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid.
MedLine Citation:
PMID:  15814253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although controversial, Creosote bush, Larrea tridentata (Sesse and Moc. ex DC) Coville, is used to treat a variety of illnesses including infertility, rheumatism, arthritis, diabetes, gallbladder and kidney stones, pain and inflammation. Recently, it has been used as a nutritional supplement. The primary product extracted from this common plant of the arid regions of northern Mexico and Southwestern United States is the potent antioxidant nordihydroguaiaretic acid (NDGA). It was widely used during the 1950s as a food preservative and to preserve naturals fibers. Later it was banned after reports of toxicity during the early 1960s. Renal and hepatotoxicity are also reported for chronic use of creosote bush and NDGA. This article reviews traditional and contemporary uses and pharmacology, including toxicology of this plant widely used in Mexican traditional medicine.
Authors:
Silvia Arteaga; Adolfo Andrade-Cetto; René Cárdenas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  98     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-07     Completed Date:  2005-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  231-9     Citation Subset:  IM    
Affiliation:
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de México, 04510 México, DF, México.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants* / metabolism,  therapeutic use,  toxicity
Humans
Larrea / chemistry*
Lethal Dose 50
Liver / metabolism*
Medicine, Traditional
Mexico
Nordihydroguaiaretic Acid* / metabolism,  therapeutic use,  toxicity
Phytotherapy*
Plant Leaves
Southwestern United States
Chemical
Reg. No./Substance:
0/Antioxidants; 500-38-9/Nordihydroguaiaretic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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