| Larger variability of saccadic reaction times in schizophrenia patients. | |
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MedLine Citation:
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PMID: 19501412 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Slower mean reaction time (RT), known as psychomotor slowing, is well documented in patients with schizophrenia. Fewer studies have shown increased variability of RT in these patients suggesting a basic difference in the distribution of RT. In this study median RT and its variability were measured for visually guided saccades performed by 53 patients and 1089 control subjects. Then average cumulative RT distributions were derived for each group and the RT distribution for each group was modeled using a decision signal rising linearly to a threshold signaling the beginning of the visually guided saccade. There was a small increase in the median RT for patients while their RTs were much more variable from trial to trial leading to a difference in the average RT distribution of the patient group. The model application led to the conclusion that this difference in the distribution of RT for patients could be attributed to a basic difference in information processing leading to the decision to move the eyes to the visually presented target. This information-processing difference could be the result of a difference in the build-up of neuronal activity involved in the generation of visually guided saccades in the frontal cortex. |
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Authors:
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Nikolaos Smyrnis; Thomas Karantinos; Ioannis Malogiannis; Christos Theleritis; Asimakis Mantas; Nicholas C Stefanis; John Hatzimanolis; Ioannis Evdokimidis |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-05 |
Journal Detail:
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Title: Psychiatry research Volume: 168 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 129-36 Citation Subset: IM |
Affiliation:
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Psychiatry Department, National and Kapodistrian University of Athens, Eginition Hospital, 72 Vassilisis Sofias Ave., 11528, Athens, Greece. smyrnis@med.uoa.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Attention / physiology Decision Making / physiology Frontal Lobe / physiopathology Functional Laterality / physiology Humans Male Photic Stimulation Psychomotor Performance / physiology* Reaction Time / physiology* Saccades / physiology* Schizophrenia / diagnosis*, physiopathology Schizophrenic Psychology Signal Detection, Psychological / physiology Visual Fields / physiology Visual Perception / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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