Document Detail

Larger testes and higher inhibin B levels in Finnish than in Danish newborn boys.
MedLine Citation:
PMID:  16595596     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Recent studies showed that male reproductive health problems, such as cryptorchidism, hypospadias, testicular cancer, and low sperm quality, are more prevalent in Denmark than in Finland. OBJECTIVES: We hypothesized that, if fetal testicular dysgenesis contributed to these observations, differences in gonadal development and the hypothalamus-pituitary-testis axis would already be detectable perinatally. Thus, we investigated healthy newborn boys in both countries. DESIGN: This was a prospective, longitudinal population-based study. SETTING: Two primary obstetric centers were included at the University Hospitals of Copenhagen, Denmark, and Turku, Finland. PARTICIPANTS: The participants of the study included 633 Danish and 1044 Finnish boys, born at term with appropriate weight for gestational age. INTERVENTIONS: Ultrasound determination of testis size at 0, 3, and 18 months and blood sampling (n = 727) at 3 months were analyzed. MAIN OUTCOME MEASURES: Testicular volume and reproductive hormones were measured. RESULTS: Testis volume was significantly higher at all ages in Finnish than in Danish boys (medians, 98 vs. 95, 185 vs. 119, and 188 vs. 136 mm(3), respectively; P < 0.00001). Testis growth from birth to 3 months was larger in Finnish than in Danish boys (mean, 75 vs. 26 mm(3); P < 0.0001). Serum hormone levels were higher in Finnish than Danish boys for inhibin B (median, 456 vs. 385 pg/ml; P < 0.0001), FSH (1.33 vs. 1.21 IU/liter; P < 0.036), and SHBG (143 vs. 136 nmol/liter; P < 0.022). Inhibin B was significantly positively correlated to testicular volume (r = 0.25; P < 0.006). CONCLUSIONS: The larger testes and higher inhibin B levels most likely represent a bigger volume of seminiferous tubules in Finnish compared with Danish boys. Although this phenomenon may be attributable to a genetic difference between the two countries, it may also reflect environmental factors influencing testicular development.
Katharina M Main; Jorma Toppari; Anne-Maarit Suomi; Marko Kaleva; Marla Chellakooty; Ida M Schmidt; Helena E Virtanen; Kirsten A Boisen; Claudia M Kai; Ida N Damgaard; Niels E Skakkebaek
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-04
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  91     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-07     Completed Date:  2006-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2732-7     Citation Subset:  AIM; IM    
University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
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MeSH Terms
Analysis of Variance
Birth Weight
Follicle Stimulating Hormone / blood
Gestational Age
Infant, Newborn
Inhibins / blood*
Longitudinal Studies
Luteinizing Hormone / blood
Prospective Studies
Sex Hormone-Binding Globulin / analysis
Testis / anatomy & histology*,  growth & development,  ultrasonography
Reg. No./Substance:
0/Sex Hormone-Binding Globulin; 0/inhibin B; 57285-09-3/Inhibins; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone
Comment In:
J Clin Endocrinol Metab. 2006 Jul;91(7):2503-5   [PMID:  16825576 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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