Document Detail

Larger Biopsies Evaluation of Transient Elastography for Detecting Advanced Fibrosis in Patients with Compensated Chronic Hepatitis B.
MedLine Citation:
PMID:  22414330     Owner:  NLM     Status:  Publisher    
Objective:  Although larger biopsies sample had been recommended for study of non-invasive liver fibrosis assessment, few studies with larger biopsies for transient elastography (TE) detecting liver fibrosis had been reported. Present study tries to re-evaluate performance of TE for detecting advanced fibrosis (≥F3) with larger biopsies in patients with compensated chronic hepatitis B. Methods:  A total of 375 compensated patients were analyzed, which had undergone liver biopsy, reliable TE and routine blood tests. Results:  The area under receiver operating characteristic curve (AUC) was influenced by liver biopsy sample: 0.873 (95% confidence interval 0.838-0.909) in total patients, 0.880 (0.844-0.917) in length ≥15mm, 0.897 (0.863-0.932) in length ≥20mm and 0.911 (0.874-0.949) in length ≥25mm. In patients with sample length ≥20mm, the cutoffs to exclude and confirm advanced fibrosis were 7.1kPa and 12.7kPa, respectively. Stratified by ALT 2×ULN, transient elastography detecting advanced fibrosis with the most efficiency by 72.5% of patients obviated from liver biopsy. In patients with normal bilirubin and ALT <2×ULN, the area was 0.921 (0.860-0.982), and cutoffs for excluding and confirming diagnosis were 7.4kPa and 10.6kPa, respectively; 80% of patients could be classified with or without AF. In patients with normal bilirubin and ALT ≥2×ULN, the corresponding numbers were 0.885 (0.824-0.947), 7.5kPa, 12.7kPa and 79.2%, respectively. Conclusions:  Inadequate sample study would underestimate the efficiency of TE on detecting advanced fibrosis. With ALT 2×ULN stratified cutoffs, TE determined nearly 80% of patients with normal bilirubin as AF or non-AF and obviated them from liver biopsies. © 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Yong Peng Chen; Xie Er Liang; Qi Zhang; Jie Peng; You Fu Zhu; Wei Qun Wen; Jin Lin Hou
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-13
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Department of Infectious Disease, Nanfang Hospital, Institute for Hepatology Research, Southern Medical University, Guangzhou, 510515, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Complete sequence analysis of 18S rDNA based on genomic DNA extraction from individual Demodex mites...
Next Document:  Sentence repetition and digit span: Potential markers of bilingual children with suspected SLI?