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Largen: a molecular regulator of Mammalian cell size control.
MedLine Citation:
PMID:  24656129     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Little is known about how mammalian cells maintain cell size homeostasis. We conducted a novel genetic screen to identify cell-size-controlling genes and isolated Largen, the product of a gene (PRR16) that increased cell size upon overexpression in human cells. In vitro evidence indicated that Largen preferentially stimulates the translation of specific subsets of mRNAs, including those encoding proteins affecting mitochondrial functions. The involvement of Largen in mitochondrial respiration was consistent with the increased mitochondrial mass and greater ATP production in Largen-overexpressing cells. Furthermore, Largen overexpression led to increased cell size in vivo, as revealed by analyses of conditional Largen transgenic mice. Our results establish Largen as an important link between mRNA translation, mitochondrial functions, and the control of mammalian cell size.
Authors:
Kazuo Yamamoto; Valentina Gandin; Masato Sasaki; Susan McCracken; Wanda Li; Jennifer Liepa Silvester; Andrew J Elia; Feng Wang; Yosuke Wakutani; Roumiana Alexandrova; Yathor D Oo; Peter J Mullen; Satoshi Inoue; Momoe Itsumi; Valentina Lapin; Jillian Haight; Andrew Wakeham; Arda Shahinian; Mitsuhiko Ikura; Ivan Topisirovic; Nahum Sonenberg; Tak W Mak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular cell     Volume:  53     ISSN:  1097-4164     ISO Abbreviation:  Mol. Cell     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-03-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802571     Medline TA:  Mol Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  904-15     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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