Document Detail


Large vessel occlusion, cerebral infarction and thrombocytopenia in the "primary" antiphospholipid syndrome. Response to anticoagulation.
MedLine Citation:
PMID:  1905598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 65-year-old white female without lupus developed concurrent thrombocytopenia and disturbed arterial circulation to the brain and lower leg (a minor stroke and lower leg gangrene, necessitating amputation). Laboratory studies disclosed high levels of anticardiolipin antibodies. Anticoagulant treatment restored circulation in the remaining leg and also normalized platelet levels. This case emphasizes the importance of searching for anticardiolipin antibodies in unexplained thrombotic events.
Authors:
H Locht; F D Lindström; A Herder
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  9     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-08-06     Completed Date:  1991-08-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Affiliation:
Department of Medicine, University Hospital, Linköping, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antibodies / analysis*
Anticoagulants / therapeutic use*
Blood Coagulation Factors / analysis,  immunology
Cardiolipins / immunology
Cerebral Infarction / complications*,  drug therapy
Female
Gangrene / etiology
Humans
Leg / blood supply*
Lupus Coagulation Inhibitor
Phospholipids / immunology*
Syndrome
Thrombocytopenia / complications*
Thrombosis / complications
Vascular Diseases / complications*,  drug therapy
Chemical
Reg. No./Substance:
0/Antibodies; 0/Anticoagulants; 0/Blood Coagulation Factors; 0/Cardiolipins; 0/Lupus Coagulation Inhibitor; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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