Document Detail

Large vessel occlusion, cerebral infarction and thrombocytopenia in the "primary" antiphospholipid syndrome. Response to anticoagulation.
MedLine Citation:
PMID:  1905598     Owner:  NLM     Status:  MEDLINE    
A 65-year-old white female without lupus developed concurrent thrombocytopenia and disturbed arterial circulation to the brain and lower leg (a minor stroke and lower leg gangrene, necessitating amputation). Laboratory studies disclosed high levels of anticardiolipin antibodies. Anticoagulant treatment restored circulation in the remaining leg and also normalized platelet levels. This case emphasizes the importance of searching for anticardiolipin antibodies in unexplained thrombotic events.
H Locht; F D Lindström; A Herder
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  9     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-08-06     Completed Date:  1991-08-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Department of Medicine, University Hospital, Linköping, Sweden.
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MeSH Terms
Antibodies / analysis*
Anticoagulants / therapeutic use*
Blood Coagulation Factors / analysis,  immunology
Cardiolipins / immunology
Cerebral Infarction / complications*,  drug therapy
Gangrene / etiology
Leg / blood supply*
Lupus Coagulation Inhibitor
Phospholipids / immunology*
Thrombocytopenia / complications*
Thrombosis / complications
Vascular Diseases / complications*,  drug therapy
Reg. No./Substance:
0/Antibodies; 0/Anticoagulants; 0/Blood Coagulation Factors; 0/Cardiolipins; 0/Lupus Coagulation Inhibitor; 0/Phospholipids

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