Document Detail

Large-vessel arteritis associated with chronic active Epstein-Barr virus infection.
MedLine Citation:
PMID:  9485096     Owner:  NLM     Status:  MEDLINE    
This report describes an autopsy case of large-vessel arteritis associated with chronic active Epstein-Barr virus (EBV) infection in a 10-year-old Japanese girl. All of the 3 main coronary arteries, bilateral common carotid and subclavian arteries, abdominal aorta and its major branches, and bilateral common iliac arteries were involved, and all showed aneurysmal dilation of the lumens. Histopathologic examination revealed mesoarteritis characterized by moth-eaten-appearing destruction of the medial elastic laminae, with T lymphocyte infiltration around the vasa vasorum and severe intimal thickening. The EBV DNA genome was detected in the diseased aortic tissue by polymerase chain reaction, and in the infiltrating lymphocytes by in situ hybridization. The clinical symptoms and histopathologic manifestations of the arterial lesions in this patient were obviously different from those of Kawasaki disease and Takayasu arteritis, and the arteritis was considered to be associated with the EBV infection.
K Murakami; M Ohsawa; S X Hu; H Kanno; K Aozasa; M Nose
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  41     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-19     Completed Date:  1998-03-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-73     Citation Subset:  AIM; IM    
Tohoku University School of Medicine, and Tohoku Welfare Pension Hospital, Sendai, Japan.
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MeSH Terms
Arteries / pathology
Arteritis / pathology,  virology*
Elastic Tissue / pathology
Fatal Outcome
Herpesviridae Infections*
Herpesvirus 4, Human*
Tumor Virus Infections*
Tunica Media / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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