Document Detail

Large variations in skeletal muscle carnitine level fail to modify energy metabolism in exercising rats.
MedLine Citation:
PMID:  1981035     Owner:  NLM     Status:  MEDLINE    
1. The importance of carnitine status in energy metabolism during exercise was studied in experimentally carnitine-depleted or supplemented rats. 2. Muscle carnitine concentration can be decreased by 40% with D-carnitine and increased by 40% with L-carnitine supplementation. 3. In spite of large variation of carnitine content, neither the exercising capacity nor the rate of muscle or liver glycogenolysis were modified during submaximal exercise. 4. The increased lipid metabolism induced by exercise can be adequately supported by endogenous levels of tissue carnitine. 5. Before any impairment in energy metabolism during exercise can be demonstrated, carnitine concentration has to be reduced to a level close to that measured with primary carnitine deficiency, i.e. less than 20 mumol/l of plasma.
B Simi; M H Mayet; B Sempore; R J Favier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. A, Comparative physiology     Volume:  97     ISSN:  0300-9629     ISO Abbreviation:  Comp Biochem Physiol A Comp Physiol     Publication Date:  1990  
Date Detail:
Created Date:  1991-03-26     Completed Date:  1991-03-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1276312     Medline TA:  Comp Biochem Physiol A Comp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  543-9     Citation Subset:  IM; S    
URA 1341 CNRS, Laboratoire de Physiologie, Faculté de Médecine Lyon Grange-Blanche, France.
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MeSH Terms
Carnitine / blood,  metabolism*,  pharmacology
Energy Metabolism* / drug effects
Liver / metabolism
Muscles / drug effects,  metabolism*
Physical Exertion / physiology
Rats, Inbred Strains
Reg. No./Substance:

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