Document Detail

Large telomerase RNA, telomere length heterogeneity and escape from senescence in Candida glabrata.
MedLine Citation:
PMID:  19840797     Owner:  NLM     Status:  MEDLINE    
Telomerase, the key enzyme essential for the maintenance of eukaryotic chromosome ends, contains a reverse transcriptase and an RNA that provides the template for the synthesis of telomeric repeats. Here, we characterize the telomerase subunits in the hemiascomycete yeast Candida glabrata. We propose a secondary structure model for the telomerase RNA that is the largest described to date. Telomerase deletion mutants show a progressive shortening of telomeres and a modest loss of viability. Frequent post-senescence survivors emerge that possess long telomeric repeat tracts. We suggest that the high telomere length heterogeneity accounts for this distinct senescence phenotype.
R Kachouri-Lafond; B Dujon; E Gilson; E Westhof; C Fairhead; M T Teixeira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-17
Journal Detail:
Title:  FEBS letters     Volume:  583     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3605-10     Citation Subset:  IM    
Architecture et R??activit?? de l'ARN, Universit?? de Strasbourg, CNRS, IBMC, 67084 Strasbourg, France.
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MeSH Terms
Base Sequence
Blotting, Southern
Candida glabrata / enzymology,  genetics*,  growth & development
Cell Division
DNA, Fungal / genetics
Flow Cytometry
Gene Deletion
Molecular Sequence Data
Nucleic Acid Conformation
RNA / chemistry,  genetics*
RNA, Fungal / chemistry,  genetics*
Sequence Homology, Nucleic Acid
Telomerase / chemistry,  genetics*
Telomere / genetics*
Reg. No./Substance:
0/DNA, Fungal; 0/RNA, Fungal; 0/telomerase RNA; 63231-63-0/RNA; EC

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