| Large-scale spontaneous fluctuations and correlations in brain electrical activity observed with magnetoencephalography. | |
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MedLine Citation:
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PMID: 20123024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Knowledge about the intrinsic functional architecture of the human brain has been greatly expanded by the extensive use of resting-state functional magnetic resonance imaging (fMRI). However, the neurophysiological correlates and origins of spontaneous fMRI signal changes remain poorly understood. In the present study, we characterized the power modulations of spontaneous magnetoencephalography (MEG) rhythms recorded from human subjects during wakeful rest (with eyes open and eyes closed) and light sleep. Through spectral, correlation and coherence analyses, we found that resting-state MEG rhythms demonstrated ultraslow (<0.1 Hz) spontaneous power modulations that synchronized over a large spatial distance, especially between bilaterally homologous regions in opposite hemispheres. These observations are in line with the known spatio-temporal properties of spontaneous fMRI signals, and further suggest that the coherent power modulation of spontaneous rhythmic activity reflects the electrophysiological signature of the large-scale functional networks previously observed with fMRI in the resting brain. |
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Authors:
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Zhongming Liu; Masaki Fukunaga; Jacco A de Zwart; Jeff H Duyn |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2010-02-01 |
Journal Detail:
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Title: NeuroImage Volume: 51 ISSN: 1095-9572 ISO Abbreviation: Neuroimage Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-07-08 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 102-11 Citation Subset: IM |
Affiliation:
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Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, MD 20982-1065, USA. liuz5@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / physiology* Brain Mapping / methods* Cortical Synchronization Female Functional Laterality Humans Magnetoencephalography / methods* Male Periodicity Rest Signal Processing, Computer-Assisted Sleep / physiology Time Factors Visual Perception / physiology Wakefulness / physiology |
| Grant Support | |
ID/Acronym/Agency:
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Z99 NS999999/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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