| Large scale, postlicensure, selective vaccination of Chilean infants with PRP-T conjugate vaccine: practicality and effectiveness in preventing invasive Haemophilus influenzae type b infections. | |
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MedLine Citation:
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PMID: 8852909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Haemophilus influenzae type b (Hib) conjugate vaccines have demonstrated an impressive impact in diminishing Hib disease in industrialized countries. However, their high cost prompts nonindustrialized countries to corroborate their effectiveness under local conditions before considering their programmatic implementation. Such a postlicensure evaluation of vaccine effectiveness was undertaken in Chile. METHODS: After its licensure in Chile polyribosylribitol phosphate-tetanus toxoid protein conjugate vaccine (PRP-T), combined with diphtheria-tetanus-pertussis vaccine, was introduced into the Expanded Program on Immunization schedules in 36 health centers throughout metropolitan Santiago for 12 months, whereas 35 similar health centers administered only diphtheria-tetanus toxoid-pertussis vaccine. Bacteriologic surveillance data for invasive Hib cases collected over the ensuing 30 months were analyzed. RESULTS: In an intent-to-vaccinate (effectiveness) analysis, PRP-T provided 90.2% protection (95% confidence interval, 74.5 to 100%) against invasive Hib disease (40 vs. 4 cases, P < 0.001). Vaccine effectiveness was 91.3% against meningitis (22 vs. 2 cases) and 80% against pneumonia and empyema (10 vs. 2 cases, P = 0.039). Vaccine efficacy among infants who received all three doses of PRP-T was 91.7% (95% confidence interval, 64.8 to 100%). CONCLUSIONS: Programmatic use of Hib conjugate vaccine administered in combination with diphtheria-tetanus-pertussis vaccine constitutes a highly effective and practical intervention in Chile, a newly industrializing country. |
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Authors:
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R Lagos; I Horwitz; J Toro; O San Martin; P Abrego; C Bustamante; S S Wasserman; O S Levine; M M Levine |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 15 ISSN: 0891-3668 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-12-05 Completed Date: 1996-12-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 216-22 Citation Subset: IM |
Affiliation:
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Centro para Vacunas en Desarrollo-Chile, Santiago. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Capsules Chile Diphtheria-Tetanus-Pertussis Vaccine / immunology* Haemophilus Infections / epidemiology, prevention & control* Haemophilus Vaccines / immunology* Haemophilus influenzae / immunology* Humans Incidence Infant Polysaccharides, Bacterial / immunology* Vaccination* Vaccines, Combined / immunology* Vaccines, Conjugate / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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N01 AL45251//PHS HHS; U01 AL35948//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Capsules; 0/Diphtheria-Tetanus-Pertussis Vaccine; 0/Haemophilus Vaccines; 0/Haemophilus influenzae type b polysaccharide vaccine; 0/Polysaccharides, Bacterial; 0/Vaccines, Combined; 0/Vaccines, Conjugate; 0/diphtheria-tetanus-pertussis-haemophilus b conjugate vaccine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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