Document Detail


Large-scale manufacture of peptide therapeutics by chemical synthesis.
MedLine Citation:
PMID:  12815383     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The large-scale commercial production of a 36-amino-acid peptide by chemical synthesis has been demonstrated in the development of enfuvirtide (T-20 or Fuzeon), a first-in-class membrane fusion inhibitor for the treatment of HIV. The rationale behind route selection and the scale-up of the process used to manufacture enfuvirtide are discussed.
Authors:
Brian L Bray
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature reviews. Drug discovery     Volume:  2     ISSN:  1474-1776     ISO Abbreviation:  Nat Rev Drug Discov     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-19     Completed Date:  2003-07-22     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  101124171     Medline TA:  Nat Rev Drug Discov     Country:  England    
Other Details:
Languages:  eng     Pagination:  587-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / chemical synthesis*
HIV Envelope Protein gp41
Peptide Fragments / chemical synthesis*
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/HIV Envelope Protein gp41; 0/Peptide Fragments; 19OWO1T3ZE/enfuvirtide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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