Document Detail

Large pericardial effusions due to systemic lupus erythematosus: a report of eight cases.
MedLine Citation:
PMID:  16038109     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to describe the clinical, echocardiographic and laboratory characteristics of large pericardial effusions and cardiac tamponade secondary to systemic lupus erythematosus (SLE). An ongoing prospective study was conducted at Tygerberg Academic Hospital, South Africa between 1996 and 2002. All patients older than 13 years presenting with large pericardial effusions (> 10 mm) requiring pericardiocentesis were included. Eight cases (out of 258) were diagnosed with SLE. The mean (SD) age was 29.5 (10.7) years. Common clinical features were Raynaud's phenomenon, arthralgia and lupus nephritis class III/IV. Echocardiography showed Libman-Sacks endocarditis (LSE) in all the mitral valves. Two patients developed transient left ventricular dysfunction; both these patients had pancarditis. Typical serological findings included antinuclear antibodies, anti-double stranded DNA antibodies, low complement C4 levels and low C3 levels. CRP was elevated in six cases. Treatment consisted of oral steroids and complete drainage of the pericardial effusions. No repeat pericardial effusions or constrictive pericarditis developed amongst the survivors (3.1 years follow up). This study concludes that large pericardial effusions due to SLE are rare, and associated with nephritis, LSE and myocardial dysfunction. Treatment with steroids and complete drainage is associated with a good cardiac outcome.
H S v H Weich; L J Burgess; H Reuter; E A Brice; A F Doubell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Lupus     Volume:  14     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-25     Completed Date:  2005-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  450-7     Citation Subset:  IM    
Cardiology Unit/TREAD Research, Tygerberg Hospital and Stellenbosch University, Parow, South Africa.
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MeSH Terms
Fatal Outcome
Immunosuppressive Agents / therapeutic use
Lupus Erythematosus, Systemic / complications*
Pericardial Effusion / diagnosis,  etiology*,  therapy
Prednisone / therapeutic use
Reg. No./Substance:
0/Immunosuppressive Agents; 53-03-2/Prednisone

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