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Large monophasic synovial sarcoma: a case report and review of the literature.
MedLine Citation:
PMID:  24505580     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Synovial sarcomas account for approximately 8% of all soft tissue tumors. The hallmark tumor marker is the t(X;18) translocation, which results in fusion of the SYT gene of chromosome 18 to the SSX gene of the X chromosome, creating most frequently either an SYT-SSX1 or SYT-SSX2 transfusion transcript. Clinically, synovial sarcomas most often present on the extremities and average roughly 7 cm in diameter. Metastatic spread to regional lymph nodes and/or the lungs is common. Because the incidence of this tumor is low, most studies have been retrospective; therefore, management and prognostic interpretation has remained controversial. We report a case of a patient who presented with a slowly growing, unusually large mass on the left forearm of 10 years' duration. A diagnosis of monophasic synovial sarcoma was confirmed by biopsy. We also review the literature regarding management strategies for synovial sarcomas.
Authors:
David Silverstein; Peter Klein
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cutis     Volume:  93     ISSN:  2326-6929     ISO Abbreviation:  Cutis     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  IM    
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