Document Detail

Large litter size increases maternal energy intake but has no effect on UCP1 content and serum-leptin concentrations in lactating Brandt's voles (Lasiopodomys brandtii).
MedLine Citation:
PMID:  18283466     Owner:  NLM     Status:  MEDLINE    
Lactation is the most energetically demanding period in the female mammal's life. We measured maternal energy intake, uncoupling protein 1 (UCP1) content in brown adipose tissue (BAT), serum-leptin concentration, and litter growth in lactating Brandt's voles (Lasiopodomys brandtii) with different litter sizes. Litter mass was positively related to litter size but there was no difference in pup mass at birth. Maternal gross energy intake at peak lactation was positively correlated with litter size and litter mass. Maternal resting metabolic rate (RMR) was positively correlated with litter mass, but not with litter size. No significant differences were detected in body-fat mass, serum-leptin concentration, or UCP1 in lactating voles with different litter sizes. Serum-leptin concentration was negatively correlated with energy intake during lactation. Our data did not support the hypothesis that there is a trade-off in energy allocation between maternal maintenance and offspring growth in lactating Brandt's voles, but support the idea that if the mothers with ten pups should have less energy available for their maintenance than mothers raising fewer pups. Also, leptin is probably not the only factor that induces the high energy intake in mothers with large litter sizes, although it was involved in the regulation of energy intake during lactation.
Xue-Ying Zhang; Yu-Lian Li; De-Hua Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-19
Journal Detail:
Title:  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology     Volume:  178     ISSN:  0174-1578     ISO Abbreviation:  J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-09-22     Revised Date:  2009-06-08    
Medline Journal Info:
Nlm Unique ID:  8413200     Medline TA:  J Comp Physiol B     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  637-45     Citation Subset:  IM    
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Datun Lu, Chaoyang, Beijing 100101, People's Republic of China.
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MeSH Terms
Adipose Tissue / anatomy & histology,  metabolism
Adipose Tissue, Brown / anatomy & histology,  metabolism
Animals, Suckling
Basal Metabolism / physiology
Body Composition / physiology
Body Weight / physiology
Energy Intake / physiology*
Ion Channels / metabolism*
Lactation / physiology*
Leptin / blood*
Litter Size / physiology*
Mitochondrial Proteins / metabolism*
Organ Size / physiology
Reg. No./Substance:
0/Ion Channels; 0/Leptin; 0/Mitochondrial Proteins; 0/mitochondrial uncoupling protein

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