Document Detail

Large granular lymphocytosis, lymphocyte subset inversion, thrombocytopenia, dysproteinemia, and positive Ehrlichia serology in a dog.
MedLine Citation:
PMID:  12873028     Owner:  NLM     Status:  MEDLINE    
A 7-year-old, mixed-breed dog was presented for evaluation of a possible lymphocytic leukemia. Results of laboratory testing included thrombocytopenia, large granular lymphocytosis, inverted CD4:CD8 ratio, hyperglobulinemia, and hypoalbuminemia. Results of a tick-borne disease panel indicated a positive immunoglobulin G serum titer (1:2,048) to Ehrlichia canis, supporting exposure to this organism. The dog responded to a combination treatment of doxycycline and prednisone. A review of the literature and novel diagnostic methods that aided in the diagnosis of this case are discussed.
Heather L Heeb; Melinda J Wilkerson; Ruthanne Chun; Roman Reddy Ganta
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of the American Animal Hospital Association     Volume:  39     ISSN:  0587-2871     ISO Abbreviation:  J Am Anim Hosp Assoc     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-07-22     Completed Date:  2003-09-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0415027     Medline TA:  J Am Anim Hosp Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  IM    
Department of Clinical Sciences, Kansas State University, 106A Mosier Hall, 1800 Denison Avenue, Manhattan, Kansas 66506, USA.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage,  therapeutic use
Diagnosis, Differential
Dog Diseases / blood,  diagnosis*,  drug therapy
Doxycycline / administration & dosage,  therapeutic use
Ehrlichia canis / immunology*,  isolation & purification
Ehrlichiosis / diagnosis,  veterinary*
Immunoglobulin G / analysis
Leukemia, Lymphoid / diagnosis,  veterinary
Lymphocyte Subsets
Lymphocytosis / veterinary
Prednisone / administration & dosage,  therapeutic use
Thrombocytopenia / veterinary
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Immunoglobulin G; 53-03-2/Prednisone; 564-25-0/Doxycycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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