| Large granular lymphocytosis, lymphocyte subset inversion, thrombocytopenia, dysproteinemia, and positive Ehrlichia serology in a dog. | |
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MedLine Citation:
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PMID: 12873028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 7-year-old, mixed-breed dog was presented for evaluation of a possible lymphocytic leukemia. Results of laboratory testing included thrombocytopenia, large granular lymphocytosis, inverted CD4:CD8 ratio, hyperglobulinemia, and hypoalbuminemia. Results of a tick-borne disease panel indicated a positive immunoglobulin G serum titer (1:2,048) to Ehrlichia canis, supporting exposure to this organism. The dog responded to a combination treatment of doxycycline and prednisone. A review of the literature and novel diagnostic methods that aided in the diagnosis of this case are discussed. |
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Authors:
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Heather L Heeb; Melinda J Wilkerson; Ruthanne Chun; Roman Reddy Ganta |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of the American Animal Hospital Association Volume: 39 ISSN: 0587-2871 ISO Abbreviation: J Am Anim Hosp Assoc Publication Date: 2003 Jul-Aug |
Date Detail:
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Created Date: 2003-07-22 Completed Date: 2003-09-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0415027 Medline TA: J Am Anim Hosp Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 379-84 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences, Kansas State University, 106A Mosier Hall, 1800 Denison Avenue, Manhattan, Kansas 66506, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / administration & dosage, therapeutic use Diagnosis, Differential Dog Diseases / blood, diagnosis*, drug therapy Dogs Doxycycline / administration & dosage, therapeutic use Ehrlichia canis / immunology*, isolation & purification Ehrlichiosis / diagnosis, veterinary* Female Immunoglobulin G / analysis Leukemia, Lymphoid / diagnosis, veterinary Lymphocyte Subsets Lymphocytosis / veterinary Prednisone / administration & dosage, therapeutic use Thrombocytopenia / veterinary |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Immunoglobulin G; 53-03-2/Prednisone; 564-25-0/Doxycycline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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