Document Detail

Large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathological study of six cases.
MedLine Citation:
PMID:  12819387     Owner:  NLM     Status:  MEDLINE    
Six cases of cervical large cell neuroendocrine carcinomas (LCNEC) were found among 972 patients (0.6%) with invasive cervical carcinoma. The patients, who were from 27 to 51 (mean 38) years of age, presented with vaginal bleeding or an abnormal Papanicolaou smear. Five tumors were stage Ib and one was IIa. All patients underwent radical hysterectomy and received adjuvant chemotherapy and pelvic radiotherapy. Four patients died of tumor 6 to 19 months (mean 14 months) postoperatively. On histologic examination, the tumor cells were arranged in an organoid growth pattern and were larger than those of typical small cell carcinoma. Glandular differentiation was present in one case. Mitotic figures ranged from 15 to 45 (mean 29) per 10 high-power fields. Prominent vascular invasion and necrosis was seen in all of the tumors. Each tumor was immunoreactive for chromogranin A and/or synaptophysin. The results of this study confirm the aggressive nature of cervical LCNECs. The recognition of LCNECs is necessary to establish the most effective treatment for these aggressive tumors.
Yuichiro Sato; Tomihiro Shimamoto; Satoshi Amada; Yujiro Asada; Tohru Hayashi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  22     ISSN:  0277-1691     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-23     Completed Date:  2004-02-03     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-30     Citation Subset:  IM    
Department of Pathology, Miyazaki Prefectural Hospital, Miyazaki, Japan.
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MeSH Terms
Carcinoma, Neuroendocrine / pathology*,  therapy
Diagnosis, Differential
Fallopian Tubes / surgery
Fatal Outcome
Lung Neoplasms / secondary,  surgery
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Uterine Cervical Neoplasms / pathology*,  therapy
Uterine Hemorrhage
Vaginal Smears

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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