| Large cell neuroendocrine carcinoma arising in mature cystic teratoma: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 23091901 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Malignant transformation of ovarian mature cystic teratoma is rare, and occurs in approximately 1% of all cases. The most common histology arising in mature cystic teratoma is squamous cell carcinoma. Less frequently, malignant transformation is represented by an endocrine tumor. To date, only five cases of large cell neuroendocrine carcinoma (LCNC) arising in a mature cystic teratoma of the ovary have been reported. CLINICAL CASE: A 69-year-old woman presented with a 15-cm left ovarian mass, and was diagnosed with Stage IV large cell carcinoma neuroendocrine carcinoma (LCNC) arising in mature cystic teratoma (MCT) of the left ovary. The patient received adjuvant chemotherapy with paclitaxel and carboplatin, however, residual tumors increased in size. Six months after the debulking surgery she succumbed to the disease. A literature review revealed LCNC of the ovary showed excessively aggressive phenotype in malignant transformation from ovarian mature cystic teratoma. CONCLUSION: The present case of LCNC arising in MCT had an exceedingly poor prognosis, which was suggested in the previous five cases reported. |
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Authors:
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M Miyamoto; M Takano; T Goto; M Kato; N Sasaki; K Furuya |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of gynaecological oncology Volume: 33 ISSN: 0392-2936 ISO Abbreviation: Eur. J. Gynaecol. Oncol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100357 Medline TA: Eur J Gynaecol Oncol Country: Italy |
Other Details:
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Languages: eng Pagination: 414-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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