Document Detail


Large cell neuroendocrine carcinoma of the ampulla of vater.
MedLine Citation:
PMID:  22964952     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
CONTEXT: Large cell neuroendocrine carcinomas of the ampulla of Vater are rare and confer a very poor prognosis despite aggressive therapy. There are few case reports of large cell neuroendocrine carcinomas of the ampulla of Vater in the literature and to date no studies have been done to establish optimal management. We describe a pooled case series from published reports of neuroendocrine carcinomas of the ampulla of Vater including a case which presented to our institution.
METHODS: A narrative review was undertaken including all published English case reports of large cell neuroendocrine carcinomas of the ampulla of Vater. Our primary outcome was to determine the overall survival.
RESULTS: Twenty cases of large cell neuroendocrine carcinomas of the ampulla of Vater were identified. Seventy-six percent of patients were reported to have died of disease with a mean survival of 11.8 months. Twenty percent of the tumours were associated with an adenoma. The approximate median survivals were 15 months for those with an associated adenoma and 11 months without.
CONCLUSIONS: This pooled analysis demonstrates both the rarity and poor prognosis of large cell neuroendocrine carcinomas of the ampulla of Vater. Although surgical resection is the mainstay of treatment, we review common adjuvant chemotherapy regimes. Prognosis may be improved when these tumours are associated with adenomas, however, further studies are needed.
Authors:
Rachel E Beggs; Michael E Kelly; Omer Eltayeb; Paul Crotty; Ray McDermott; Paul F Ridgway
Publication Detail:
Type:  Journal Article     Date:  2012-09-10
Journal Detail:
Title:  JOP : Journal of the pancreas     Volume:  13     ISSN:  1590-8577     ISO Abbreviation:  JOP     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101091810     Medline TA:  JOP     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  470-5     Citation Subset:  IM    
Affiliation:
Department of Surgery, The Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital. Dublin, Ireland. ridgwayp@tcd.ie.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Analysis of Essential Oils and Fatty Acids from Platycodi Radix using Chemometric Methods and Retent...
Next Document:  Effects of porcine pancreatic enzymes on the pancreas of hamsters. Part 1: basic studies.