Document Detail

Large cell lymphoma of the orbit with microvillous projections ('porcupine lymphoma').
MedLine Citation:
PMID:  3904686     Owner:  NLM     Status:  MEDLINE    
A 57-year-old man had a diffuse mass in the lacrimal gland area associated with extensive bony destruction. A malignant epithelial tumor of the lacrimal gland was suspected clinically, and a biopsy specimen disclosed an undifferentiated malignant neoplasm of uncertain origin. Ultrastructural studies, however, revealed features of a lymphoid tumor with myriad cytoplasmic microvillous projections. The patient has had no evidence of systemic lymphoma after more than three years of follow-up. To our knowledge, this is the first report of orbital involvement of a large cell lymphoma with microvillous projections ("porcupine lymphoma"). The role of electron microscopy in the differential diagnosis of this orbital tumor was important, since epithelial tumors of the lacrimal gland are best managed by surgical excision, whereas lymphoid tumors usually respond satisfactorily to radiotherapy.
R L Font; J Shields
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  103     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-11-26     Completed Date:  1985-11-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1715-9     Citation Subset:  AIM; IM    
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MeSH Terms
Cytoplasm / ultrastructure
Follow-Up Studies
Lymphoma / diagnosis,  pathology*,  radiotherapy,  ultrastructure
Microvilli / ultrastructure
Middle Aged
Orbital Neoplasms / diagnosis,  pathology*,  radiotherapy,  ultrastructure
Tomography, X-Ray Computed

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