Document Detail

Large artery involvement in giant cell (temporal) arteritis.
MedLine Citation:
PMID:  1200525     Owner:  NLM     Status:  MEDLINE    
Of 248 patients with giant cell arteritis, 34 had evidence that the disease affected the aorta or its major branches. Symptoms suggestive of large artery involvement were intermittent claudication of an extremity, paresthesias, and Raynaud's phenomenon. Physical findings included absent or decreased large artery pulses and bruits over large arteries. Four patients presented with decreased upper extremity pulses as the initial manifestation of their arteritis. Nine other patients under treatment for temporal arteritis or polymyalgia rheumatica first developed evidence of large artery involvement as corticosteroid therapy was tapered or discontinued. Angiography, performed in 10 patients, was helpful in indicating arteritis rather than atherosclerosis as the cause of large artery disease. Three patients died with aortic rupture, and, at autopsy, widespread giant cell arteritis was found. However, when corticosteroids were given in adequate doses, the response was favorable in most patients; intermittent claudication decreased and the pulses improved.
R G Klein; G G Hunder; A W Stanson; S G Sheps
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of internal medicine     Volume:  83     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-02-13     Completed Date:  1976-02-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  806-12     Citation Subset:  AIM; IM    
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MeSH Terms
Adrenal Cortex Hormones / administration & dosage,  therapeutic use
Aortic Diseases* / complications,  radiography
Arteritis / complications*
Blood Sedimentation
Giant Cell Arteritis / complications*,  diagnosis,  drug therapy,  pathology,  radiography
Intermittent Claudication / complications
Middle Aged
Renal Artery
Urine / cytology
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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