| Large arteries and the kidney. | |
| | |
MedLine Citation:
|
PMID: 20409849 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
In subjects with chronic renal disease, high systolic blood pressure (SBP) is the most modifiable cardiovascular (CV) risk factor that enables prevention of the progression of chronic kidney disease renal failure and the occurrence of CV events. Although large-artery stiffness and wave reflections are the principal hemodynamic determinants of SBP, their precise role in the progression of chronic renal disease has been poorly investigated. However, in subjects with mild to severe renal insufficiency, increased arterial stiffness and reduced creatinine clearance are closely related, independently of age; mean arterial pressure level; and presence of other traditional risk factors, including atherosclerotic plaques. Through inflammatory mechanisms, as well as through the development of arterial calcifications (including microscopic) and sodium-related alterations in extracellular matrix composition, arterial stiffness is associated with significant SBP and increased pulse pressure (PP). In the presence of renal dysfunction, frequently observed in elderly hypertensive or diabetic subjects, or even in some living donors, the resulting increase in PP may be transmitted toward and across glomeruli, even when peripheral blood pressure values are maintained. This alteration alone may initiate glomerulosclerosis and/or tubulointerstitial damage, eventually leading to CV events. In subjects with end-stage renal disease and high CV risk, pharmacological modulation of the renin-angiotensin system has been shown to prevent independently such complications. |
| | |
Authors:
|
Michel E Safar; Tewfik Nawar; Gérard E Plante |
Related Documents
:
|
21566249 - Pathophysiological basis of albumin use in cirrhosis. 3025089 - Effects of angiotensin inhibition and renal denervation in two-kidney, one clip hyperte... 7573479 - Frequency domain of renal autoregulation in the conscious dog. 21731569 - Isolated double-chambered right ventricle in a young adult. 23117009 - Current status of renal denervation in resistant hypertension. 2730519 - Vagal afferents inhibit the antidiuresis and antinatriuresis secondary to bilateral car... 3997729 - Ventral medullary ph and ventilatory responses to hyperperfusion and hypoxia. 3350679 - Use of fiber-optic pressure transducer for intracranial pressure measurements: a prelim... 141889 - Mucopolysaccharide osmotic pressure in the measurement of interstitial pressure. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American Society of Hypertension : JASH Volume: 1 ISSN: 1933-1711 ISO Abbreviation: J Am Soc Hypertens Publication Date: 2007 May-Jun |
Date Detail:
|
Created Date: 2010-04-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101312518 Medline TA: J Am Soc Hypertens Country: United States |
Other Details:
|
Languages: eng Pagination: 169-77 Citation Subset: - |
Affiliation:
|
Faculty of Medicine, Paris Descartes University, Paris, France; Diagnosis Center, Hôtel-Dieu Hospital (AP-HP), Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular mechanism of juxtaglomerular cell hyperplasia: a unifying hypothesis.
Next Document: Chronic kidney disease and cardiovascular risk.