Document Detail


Laquinimod modulates B cells and their regulatory effects on T cells in Multiple Sclerosis.
MedLine Citation:
PMID:  22846497     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Laquinimod is an orally administered drug under development for the treatment of Multiple Sclerosis (MS), lacking a fully elucidated mode of action. We assessed the immunomodulatory effects of laquinimod in vitro on human B cells from healthy or MS patients, cultured alone or with CD4(+) T cells. Laquinimod modulated B cell markers, mainly by increasing the regulatory ones CD25, IL10 and CD86, and decreased IL4, while increasing IL10 and TGFβ in both B and T cells, in a B cell-mediated manner. These findings shed additional light on the mechanisms underlying the effects of laquinimod in MS and potentially other immune-mediated diseases.
Authors:
Elias Toubi; Shahar Nussbaum; Elsebeth Staun-Ram; Ayelet Snir; Doron Melamed; Liat Hayardeny; Ariel Miller
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-28
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  -     ISSN:  1872-8421     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 31096 Haifa, Israel; Division of Clinical Immunology, Bnai-Zion Medical Center, 31048 Haifa, Israel.
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