| Laparoscopic salpingocentesis using methotrexate in combination with oral mifepristone for successful treatment of interstitial pregnancy: a case report. | |
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MedLine Citation:
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PMID: 19819446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report two cases of women who presented with amenorrhea, lower abdominal pain, and vaginal bleeding and who were diagnosed with advanced interstitial pregnancy after initial negative laparoscopies. DESIGN: Case report. SETTING: Early pregnancy unit of district general hospital. PATIENT(S): A 39-year-old woman with a history of right salpingectomy for ectopic pregnancy and a 28-year-old woman with a history of miscarriage. INTERVENTION(S): Laparoscopic salpingocentesis with methotrexate (50 mg/m(2)) after aspiration of an equivalent amount of amniotic fluid. The remainder, based on the calculated dose, was given intramuscularly. Oral mifepristone (200 mg) was given postoperatively. MAIN OUTCOME MEASURE(S): Complete resolution of interstitial pregnancy in both instances with two subsequent, successful intrauterine pregnancies delivered at term in the second patient. There were no intraoperative or postoperative complications. RESULT(S): Expected decline in beta human chorionic gonadotropin (beta-hCG) levels without the need for any further intervention(s). CONCLUSION(S): Interstitial pregnancy may be successfully and safely managed by the use of laparoscopic salpingocentesis with methotrexate and mifepristone despite high initial beta-hCG levels. |
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Authors:
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Latika Narang; Gregory Kalu |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-10-12 |
Journal Detail:
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Title: Fertility and sterility Volume: 92 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2038.e5-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Princess Royal Hospital, Haywards Heath, West Sussex, United Kingdom. latikaong@yahoo.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage Abortifacient Agents, Steroidal / administration & dosage Administration, Oral Adult Amniotic Fluid Combined Modality Therapy Fallopian Tubes / surgery Female Humans Laparoscopy / methods* Methotrexate / administration & dosage* Mifepristone / administration & dosage* Pregnancy Pregnancy, Tubal / drug therapy*, surgery* Suction / methods |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 0/Abortifacient Agents, Steroidal; 59-05-2/Methotrexate; 84371-65-3/Mifepristone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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