Document Detail

Laparoscopic repair of perforated peptic ulcers. The role of laparoscopy in generalised peritonitis.
MedLine Citation:
PMID:  10700758     Owner:  NLM     Status:  MEDLINE    
This non-randomised concurrent cohort study conducted in two teaching hospital Departments of Surgery examined the assumption that the benefits of elective laparoscopic upper gastrointestinal surgery would apply to those with generalised peritonitis due to perforated peptic ulcers. It compared 20 consecutive laparoscopic repairs of perforated peptic ulcers with a concurrent group of 16 consecutive open repairs. There were no differences pre-operatively between the two groups. The mean duration of surgery was similar (P = 0.46). There were no differences in the rate of GI tract recovery, but opiate analgesia requirement in the laparoscopic group was significantly less (P < 0.0001). Intensive care was required in three patients in the laparoscopic group (two with renal failure) and two in the open (no renal failure). Two patients in the laparoscopic and one in the open group died. The median duration of stay was five days in the laparoscopic group and six in the open. This comparison shows that the patho-physiological insult of laparoscopy in the setting of generalised peritonitis does not obviously increase the peri-operative risk of organ failure but objective benefits are small.
G S Robertson; S A Wemyss-Holden; G J Maddern
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Annals of the Royal College of Surgeons of England     Volume:  82     ISSN:  0035-8843     ISO Abbreviation:  Ann R Coll Surg Engl     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-09     Completed Date:  2000-03-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7506860     Medline TA:  Ann R Coll Surg Engl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  IM    
Department of Surgery, Leicester Royal Infirmary, UK.
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MeSH Terms
Aged, 80 and over
Analgesics, Opioid / administration & dosage
Drug Administration Schedule
Duodenal Ulcer / complications*
Hospital Mortality
Intensive Care
Intraoperative Period
Middle Aged
Peptic Ulcer Perforation / mortality,  surgery*
Peritonitis / surgery*
Reg. No./Substance:
0/Analgesics, Opioid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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