| Laparoscopic-assisted versus open ileocolic resection for Crohn's disease: a randomized trial. | |
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MedLine Citation:
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PMID: 16432345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the study was to compare laparoscopic-assisted and open ileocolic resection for primary Crohn's disease in a randomized controlled trial. METHODS: Sixty patients were randomized for laparoscopic-assisted or open surgery. Primary outcome parameter was postoperative quality of life (QoL) during 3 months of follow-up, measured by SF-36 and GIQLI questionnaire. Secondary parameters were operating time, morbidity, hospital stay, postoperative morphine requirement, pain, and costs. RESULTS: Patient characteristics were not different. Conversion rate was 10% (n=3). Median operating time was longer in laparoscopic compared with open surgery (115 versus 90 minutes; P<0.003). Hospital stay was shorter in the laparoscopic group (5 versus 7 days; P=0.008). The number of patients with postoperative morbidity within the first 30 days differed between the laparoscopic and open group (10% versus 33%; P=0.028). There was no statistically significant difference in QoL between the groups during follow-up. Significant time effects were found on all scales of the SF-36 (P<0.001) and the GIQLI score (P<0.001). QoL declined in the first week, returned to baseline levels after 2 weeks, and was improved 4 weeks and 3 months after surgery. Median overall costs during the 3 months follow-up were significantly different: euro6412 for laparoscopic and euro8196 for open surgery (P=0.042). CONCLUSIONS: Although QoL measured by SF-36 and GIQLI questionnaires was not different for laparoscopic-assisted compared with the open ileocolic resection, morbidity, hospital stay, and costs were significantly lower. |
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Authors:
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Stefan Maartense; Mich S Dunker; J Frederik M Slors; Miguel A Cuesta; Erik G J M Pierik; Dirk J Gouma; Daan W Hommes; Miriam A Sprangers; Willem A Bemelman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Annals of surgery Volume: 243 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-24 Completed Date: 2006-03-16 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: United States |
Other Details:
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Languages: eng Pagination: 143-9; discussion 150-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Academic Medical Center, Amsterdam, the Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chi-Square Distribution Crohn Disease / surgery* Digestive System Surgical Procedures / methods* Female Hospital Costs Humans Ileum Laparoscopy* Length of Stay / statistics & numerical data Male Middle Aged Netherlands Postoperative Complications Prospective Studies Quality of Life Statistics, Nonparametric Treatment Outcome |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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