Document Detail


Laparoscopic Roux-en-Y Gastric Bypass for Type 2 Diabetes Mellitus in Nonobese Chinese Patients.
MedLine Citation:
PMID:  25054568     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND:: Although bariatric surgery performed for morbid obesity has been shown to significantly improve type 2 diabetes mellitus (T2DM), data on its effectiveness to improve T2DM in nonobese patients are scarce. The present pilot study evaluated the clinical effects of laparoscopic Roux-en-Y gastric bypass surgery (LRYGB) in Chinese T2DM patients with body mass index (BMI) ≤27.5 kg/m.
MATERIALS AND METHODS:: A total of 68 consecutive patients with uncontrolled T2DM underwent LRYGB from May 2010 to March 2012. All patients were subjected to follow-up controls with anthropometric and metabolic indices at 1, 3, 6, and 12 months after surgery. Glycemic control was evaluated.
RESULTS:: One year after the surgery, LRYGB resulted in 69.4%±52.2% excess weight loss percentage (%EWL), remission of T2DM in 80.9% of all the patients. In the group of T2DM patients with BMI≤27.5 kg/m (n=28), 9 (32.1%) cases showed T2DM remission, 10 (35.7%) showed glycemic control, 7 (25%) showed improvement, and 2 (7.1%) were unchanged. The change in BMI, waist circumference, and the plasma levels of FPG, HbA1C, triglycerides, HDL-C, and insulin were statistically significance at 1 year (P<0. 05). There was no perioperative mortality, but 6 (8.8%) patients experienced complications.
CONCLUSIONS:: LRYGB resulted in significant weight loss and remission of T2DM in Chinese patients. Despite a lower response rate of surgery treatment compared with obese patients, T2DM patients with BMI≤27.5 kg/m still exhibited improvement and remission of T2DM. Diabetic patients should consider bariatric surgery, especially if traditional pharmacotherapy has not been effective. Longer follow-up is required for better evaluation.
Authors:
Jun Yin; Lu Xu; Zhongqi Mao; Xiaojun Zhou; Zheng Zhu; Xin Chen; Jie Sun; Liqian Mu; Chengjuan Peng; Haixin Qian; Yi Yang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-22
Journal Detail:
Title:  Surgical laparoscopy, endoscopy & percutaneous techniques     Volume:  -     ISSN:  1534-4908     ISO Abbreviation:  Surg Laparosc Endosc Percutan Tech     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888751     Medline TA:  Surg Laparosc Endosc Percutan Tech     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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