| Lanthanum inhibits surfactant secretion stimulated by lung distension in newborn rabbits. | |
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MedLine Citation:
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PMID: 1896265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of lanthanum on lung phospholipid secretion stimulated by lung distension was examined in 29.5-d gestation newborn rabbits. Lung lavage with saline alone produced 608 +/- 109 micrograms phospholipid/lung (mean +/- SEM), whereas lavage with 10(-3) M lanthanum produced only 153 +/- 40 micrograms phospholipid/lung (p less than 0.05), the difference in yield being attributed to inhibited lavage-induced secretion with lanthanum. If this interpretation is correct, then an increased residual tissue surfactant should be found in lanthanum-lavaged lungs. Postlavaged lung was separated into IA, IB, and IC fractions by homogenization and then centrifugation with 0.25 and 0.65 M sucrose. The surfactant IB fraction was 763 +/- 65 micrograms phospholipid/g wet lung for saline-lavaged lungs, but 1002 +/- 90 micrograms phospholipid/g wet lung for lanthanum-lavaged lungs (p less than 0.002). This confirms that decreased secretion with lanthanum was associated with increased residual surfactant in postlavaged lung. It is concluded that lanthanum is a potent inhibitor of surfactant secretion stimulated by lung distension. |
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Authors:
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A Corbet; M Owens |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatric research Volume: 30 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-10-24 Completed Date: 1991-10-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 190-2 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Irrigation Lanthanum / pharmacology* Lung / drug effects*, metabolism Phospholipids / isolation & purification* Pulmonary Surfactants / secretion* Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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RR-05425/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phospholipids; 0/Pulmonary Surfactants; 7439-91-0/Lanthanum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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