| Lansoprazole inhibits mitochondrial superoxide production and cellular lipid peroxidation induced by indomethacin in RGM1 cells. | |
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MedLine Citation:
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PMID: 21765603 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lansoprazole is effective in healing non-steroidal anti-inflammatory drugs induced ulcers, and antioxidant properties have been thought to play a key role in healing ulcers. We hypothesize that lansoprazole exerts a cytoprotective effect by inhibiting reactive oxygen species leakage from mitochondria and lipid peroxidation. We pretreated gastric epithelial RGM1 cells with lansoprazole and then treated them with indomethacin in vitro. We found that the lansoprazole pretreatment significantly reduced cellular injury, maintained mitochondrial transmembrane potential, and decreased lipid peroxidation. Furthermore, the signal intensity of the electron spin resonance spectrum of the indomethacin-treated mitochondria which were pretreated with lansoprazole showed considerable reduction compared to those without the lansoprazole pretreatment. These results suggest that lansoprazole reduced superoxide production in the mitochondria of indomethacin treated cells, and subsequently inhibited lipid peroxide and cellular injury in gastric epithelial cells. |
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Authors:
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Kanho Rai; Hirofumi Matsui; Tsuyoshi Kaneko; Yumiko Nagano; Osamu Shimokawa; Jumpei Udo; Aki Hirayama; Ichinosuke Hyodo; Hiroko P Indo; Hideyuki J Majima |
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Publication Detail:
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Type: Journal Article Date: 2011-06-17 |
Journal Detail:
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Title: Journal of clinical biochemistry and nutrition Volume: 49 ISSN: 1880-5086 ISO Abbreviation: J Clin Biochem Nutr Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700907 Medline TA: J Clin Biochem Nutr Country: Japan |
Other Details:
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Languages: eng Pagination: 25-30 Citation Subset: - |
Affiliation:
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Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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