Document Detail

Lansoprazole-based sequential and concomitant therapy for the first-line Helicobacter pylori eradication.
MedLine Citation:
PMID:  22435509     Owner:  NLM     Status:  Publisher    
OBJECTIVE:  The aim of this prospective study was to compare the efficacy of the first-line lansoprazole-based sequential therapy and concomitant therapy (lansoprazole, amoxicillin, clarithromycin and metronidazole) for Helicobacter pylori (H. pylori) eradication. METHODS:  A total of 169 patients with H. pylori infection were randomly assigned to either the sequential therapy group (n = 85) or the concomitant therapy group (n = 84). A follow-up endoscopy or urea breath test was examined at least 12 weeks after eradication. RESULTS:  Comparable H. pylori eradication rate was observed in both the sequential therapy and concomitant therapy groups by either intention-to-treat analysis [sequential 80.0% (68/85) vs concomitant 88.1% (74/84); P = 0.27] or per protocol analysis [sequential, 85.3% (64/75) vs concomitant, 94.6% (70/74); P = 0.60]. Adverse effects were reported and good compliance was observed in both groups (P = 0.72). Although dual antibiotics resistance affected the therapeutic efficacy of sequential therapy (P = 0.03), not concomitant therapy (P = 0.74), it was not an independent factor for predicting the treatment outcome. CONCLUSION:  First-line lansoprazole-based sequential and concomitant therapy were well-tolerated and comparable in terms of their H. pylori eradication rate.
Yao-Kang Huang; Meng-Chieh Wu; Sophie Sw Wang; Chao-Hung Kuo; Yi-Chern Lee; Ling-Li Chang; Tsung-Hsi Wang; Yen-Hsu Chen; Wen-Ming Wang; Deng-Chyang Wu; Fu-Chen Kuo
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Publication Detail:
Journal Detail:
Title:  Journal of digestive diseases     Volume:  13     ISSN:  1751-2980     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  232-238     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Division of Gastroenterology, Department of Internal Medicine, Ten Chan Hospital, Chung-Li, Taoyuan Division of Gastroenterology Division of Infectious Diseases, Department of Internal Medicine Cancer Center, Kaohsiung Medical University Hospital Department of Medicine Department of Microbiology, Faculty of Medicine, College of Medicine Department of Public Health, College of Health Sciences, Kaohsiung Medical University Department of Health Management, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, China.
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