Document Detail


Lanomycin and glucolanomycin, antifungal agents produced by Pycnidiophora dispersa. II. Structure elucidation.
MedLine Citation:
PMID:  1577659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two novel antifungal agents, lanomycin and glucolanomycin, as well as a biologically inactive degradation product, lanomycinol, were isolated from liquid fermentations of Pycnidiophora dispersa. All three compounds share an E,E,E-triene appended to a pyran ring. Lanomycin contains a glycine ester and glucolanomycin possesses a glucose unit attached to the glycine nitrogen. The structures, including absolute stereochemistry, were determined by spectroscopic analysis and partial chemical degradation. Both of the glycine containing compounds show activity against several pathogenic fungi in vitro.
Authors:
D W Phillipson; J O'Sullivan; J H Johnson; M S Bolgar; A D Kahle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  45     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-09     Completed Date:  1992-06-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  313-9     Citation Subset:  IM    
Affiliation:
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, N.J. 08543-4000.
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MeSH Terms
Descriptor/Qualifier:
Aminoglycosides
Anti-Bacterial Agents / chemistry*
Antifungal Agents / chemistry*
Ascomycota / metabolism
Molecular Conformation
Pyrans / chemistry*
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Pyrans; 141363-91-9/lanomycin; 141363-92-0/glucolanomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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