| Language dysfunction after stroke and damage to white matter tracts evaluated using diffusion tensor imaging. | |
| | |
MedLine Citation:
|
PMID: 18039757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Knowledge of the anatomic basis of aphasia after stroke has both theoretic and clinical implications by informing models of cortical connectivity and providing data for diagnosis and prognosis. In this study we use diffusion tensor imaging to address the relationship between damage to specific white matter tracts and linguistic deficits after left hemisphere stroke. MATERIALS AND METHODS: Twenty patients aged 38-77 years with a history of stroke in the left hemisphere underwent diffusion tensor imaging, structural MR imaging, and language testing. All of the patients were premorbidly right handed and underwent imaging and language testing at least 1 month after stroke. RESULTS: Lower fractional anisotropy (FA) values in the superior longitudinal and arcuate fasciculi of the left hemisphere, an indication of greater damage to these tracts, were correlated with decreased ability to repeat spoken language. Comprehension deficits after stroke were associated with lower FA values in the arcuate fasciculus of the left hemisphere. The findings for repetition were independent of MR imaging ratings of the degree of damage to cortical areas of the left hemisphere involved in language function. There were no findings for homotopic tracts in the right hemisphere. CONCLUSION: This study provides support for a specific role for damage to the superior longitudinal and arcuate fasciculi in the left hemisphere in patients with deficits in repetition of speech in aphasia after stroke. |
| | |
Authors:
|
J I Breier; K M Hasan; W Zhang; D Men; A C Papanicolaou |
Related Documents
:
|
10588107 - Acute stroke evaluated by time-to-peak mapping during initial and early follow-up perfu... 7490597 - Cerebrovascular disease in children under 16 years of age in the city of dijon, france:... 14607297 - Distinguishing ischemic stroke from the stroke-like lesions of melas using apparent dif... 10992307 - Whole brain quantitative cbf, cbv, and mtt measurements using mri bolus tracking: imple... 9485057 - Diffusion-weighted mri in transient global amnesia: elevated signal intensity in the le... 19085087 - Facilitated acquisition of whole-heart coronary magnetic resonance angiography with vis... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural Date: 2007-11-26 |
Journal Detail:
|
Title: AJNR. American journal of neuroradiology Volume: 29 ISSN: 1936-959X ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2008 Mar |
Date Detail:
|
Created Date: 2008-03-13 Completed Date: 2008-04-23 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
|
Languages: eng Pagination: 483-7 Citation Subset: IM |
Affiliation:
|
Division of Clinical Neurosciences, Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX 77098, USA. joshua.i.breier@uth.tmc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aphasia / diagnosis, etiology* Demyelinating Diseases / etiology*, pathology* Diffusion Magnetic Resonance Imaging / methods* Female Humans Male Middle Aged Nerve Fibers, Myelinated / pathology* Reproducibility of Results Sensitivity and Specificity Stroke / complications*, pathology* |
| Grant Support | |
ID/Acronym/Agency:
|
5P01 NS046588/NS/NINDS NIH HHS; P01 NS046588-05/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A T1 hyperintense perilesional signal aids in the differentiation of a cavernous angioma from other ...
Next Document: Contrast enhancement hyperdensity after endovascular coiling of intracranial aneurysms.