Document Detail

Language cortex representation: effects of developmental versus acquired pathology.
MedLine Citation:
PMID:  8687189     Owner:  NLM     Status:  MEDLINE    
Relatively little is known about language cortex representation in patients with developmental pathology and epilepsy. We report the results of mapping language by electrical stimulation of chronically implanted subdural electrodes in 34 patients (mean age, 12.2 years) evaluated for epilepsy surgery, 28 of whom had magnetic resonance imaging or histological evidence of developmental tumors or cortical dysplasia. Language cortex was identified in the temporal or frontal lobe of 19 patients (left hemisphere in 17, right hemisphere in 2), and overlapped or bordered the epileptogenic region in 12. Language cortex was not found in the frontal or temporal lobe of 15 patients (left hemisphere in 4, right hemisphere in 11) and was presumed to be contralateral to grid placement. Three patients with left-hemisphere perinatal or postnatal cerebral insults before the age of 5 years had no language in the left hemisphere, while 3 patients with insults between the ages of 6 and 16 years had preserved left-hemisphere language. Developmental lesions and early-onset seizures do not displace language cortex from prenatally determined sites, whereas lesions acquired before the age of 5 years may cause language to relocate to the opposite hemisphere, but only when language cortex is destroyed.
M Duchowny; P Jayakar; A S Harvey; T Resnick; L Alvarez; P Dean; B Levin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  40     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-21     Completed Date:  1996-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  IM    
Comprehensive Epilepsy Center and Neuroscience Program, Miami Children's Hospital, FL 33155, USA.
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MeSH Terms
Child, Preschool
Cognition Disorders / complications,  diagnosis
Developmental Disabilities / complications,  physiopathology*
Electric Stimulation
Electrodes, Implanted
Epilepsy / complications,  physiopathology
Frontal Lobe / physiopathology*
Functional Laterality
Language Tests
Magnetic Resonance Imaging
Temporal Lobe / physiopathology*
Wechsler Scales

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