| Langerin(+) dendritic cells are responsible for LPS-induced reactivation of allergen-specific Th2 responses in postasthmatic mice. | |
| | |
MedLine Citation:
|
PMID: 21048704 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Allergic asthma is a T cell-dependent inflammatory lung disease that results from complex interactions between genetic predisposition and environmental factors, including exposure to lipopolysaccharide (LPS). In this study, we have shown that airway LPS exposure was sufficient to induce airway hyperreactivity (AHR) and eosinophil recruitment in mice that had previously experienced an acute episode of allergic asthma. LPS-induced disease reactivation depended on the activation of allergen-specific CD4(+) T cells by a subset of lung langerin(+) dendritic cells (DCs) that retained the allergen. Upon LPS exposure, migration of langerin(+) DCs from lungs to draining lymph nodes increased and LPS-exposed langerin(+) DCs instructed CD4(+) T cells toward a T helper (Th) 2 response. Selective depletion of langerin(+) DCs prevented LPS-induced eosinophil recruitment and T-cell activation, further demonstrating a critical role for langerin(+) DCs in disease reactivation. This finding provides a possible explanation for the subclinical worsening of asthmatics following exposure to low-dose LPS. |
| | |
Authors:
|
A Ortiz-Stern; A Kanda; C Mionnet; J Cazareth; A Lazzari; S Fleury; D Dombrowicz; N Glaichenhaus; V Julia |
Related Documents
:
|
11402054 - Dual role of inflammatory stimuli in activation-induced cell death of mouse microglial ... 19387584 - Effects of schisandrin on transcriptional factors in lipopolysaccharide-pretreated macr... 20730374 - Human monocytes tolerant to lps retain the ability to phagocytose bacteria and generate... 18468694 - Comparison of the immunostimulatory and proinflammatory activities of candidate gram-po... 8803624 - Host immunologic augmentation for the control of infection. 17913904 - Inflammation activates the interferon signaling pathways in taste bud cells. |
Publication Detail:
|
Type: Journal Article Date: 2010-11-03 |
Journal Detail:
|
Title: Mucosal immunology Volume: 4 ISSN: 1935-3456 ISO Abbreviation: Mucosal Immunol Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101299742 Medline TA: Mucosal Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 343-53 Citation Subset: IM |
Affiliation:
|
1] Université de Nice-Sophia Antipolis, Valbonne, France [2] Institut National de la Santé et de la Recherche Médicale, Valbonne, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbra...
Next Document: Epithelial cell secretions from the human female reproductive tract inhibit sexually transmitted pat...