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Langerhans's cell histiocytosis in old subjects: two rare case reports and review of the literature.
MedLine Citation:
PMID:  22612839     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
doi: 10.1111/j.1741-2358.2012.00629.x Langerhans's cell histiocytosis in old subjects: two rare case reports and review of the literature Background:  Langerhans cell histiocytosis (LCH) is a proliferative disease of histiocyte-like cells that generally affects children; LCH onset is rare in adults; immunohistochemistry is essential to obtain the correct diagnosis, and treatment protocols are controversial. Objective:  To describe two new cases of adult onset oral LCH. Case reports:  Case 1: a 71-year-old woman, complaining of diffuse oral pain, presented with erythematous mucosal lesions; the panoramic radiograph and CT scan showed multiple mandible radiolucent areas. Immunohistochemical assay for S-100, CD1a and langerin test was essential in reaching the correct diagnosis. Case 2: a 77-year-old female patient presented with a non-painful, non-bleeding, slightly elevated erythematous palatal lesion of 6 months duration, together with a genital vulvar lesion of uncertain nature. The pathology confirmed the diagnosis of LCH. Many therapies (etoposid, radiotherapy) could induce only a clinical partial remission; Cladribine induced a complete recovery. Conclusion:  The first case was difficult to diagnose: the clinical presentation and course of the disease (LCH) in the elderly are multiple and unpredictable. An immunohistochemistry study is often essential to obtain the correct diagnosis. The second case required several therapeutic interventions: even though some cases regress spontaneously, others require systemic chemotherapy.
Authors:
Carlo Lajolo; Giuseppina Campisi; Giorgio Deli; Cristiano Littarru; Rosario Guiglia; Michele Giuliani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gerodontology     Volume:  29     ISSN:  1741-2358     ISO Abbreviation:  Gerodontology     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8215850     Medline TA:  Gerodontology     Country:  England    
Other Details:
Languages:  eng     Pagination:  e1207-14     Citation Subset:  D    
Copyright Information:
© 2012 The Gerodontology Society and John Wiley & Sons A/S.
Affiliation:
School of Dentistry, Catholic University, Largo A. Gemelli, Rome, Italy Department of Surgery and Oncology Disciplines, Sector of Oral Medicine "V. Margiotta", University of Palermo, Palermo, Italy.
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