Document Detail

Langerhans' cells, papillomaviruses and oesophageal carcinoma. A hypothesis.
MedLine Citation:
PMID:  3008355     Owner:  NLM     Status:  MEDLINE    
A hypothesis linking the concept of mucosal immune surveillance (Langerhans' cells and intra-epithelial lymphocytes) with recent evidence of human papillomavirus (HPV) infection of the oesophagus in a sequence of events which leads to squamous dysplasia and invasive carcinoma is presented. It is believed that the essential pathway to squamous carcinoma involves an aberration of the Langerhans' cell/lymphocyte network and its symbiotic relationship with squamous cells as a result of persistent HPV infection in the epithelium. Neoplastic transformation may occur when this 'at-risk' mucosa is exposed to one or several co-carcinogenic factors present in the environment. This hypothesis is supported by morphological changes present in acanthotic lesions of the oesophagus and by immunocytochemical evidence of HPV infection of the mucosa. In addition, this viewpoint offers a possible explanation for the regional variation of oesophageal carcinoma, the rising incidence of the disease, and the association with multifocal squamous carcinomas of the upper aerodigestive tract.
H Morris; S Price
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  69     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-05-14     Completed Date:  1986-05-14     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  413-7     Citation Subset:  IM    
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MeSH Terms
Cell Transformation, Neoplastic
Esophageal Diseases / immunology,  pathology
Esophageal Neoplasms / etiology*,  pathology
Esophagus / immunology,  microbiology,  pathology*
Langerhans Cells / immunology*
Lymphocytes / immunology
Mucous Membrane / immunology,  microbiology
Papillomaviridae / growth & development
Tumor Virus Infections / complications*,  immunology,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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