| Langerhans cell histiocytosis with transformation to acute leukemia showing 45,X, t(8; 21), 5q-, -Y karyotype. | |
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MedLine Citation:
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PMID: 12400613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 31 -year-old man was admitted to hospital with onset of difficulty in walking and urinary incontinence, leading to the diagnosis of Langerhans cell histiocytosis (LCH) which was replacing a thoracic vertebra. Four months after the completion of radiation therapy, he was referred to our department with persistent fever and severe pyogenic ulceration mainly affecting the right-hip. A diagnosis of acute non-lymphoblastic leukemia (ANLL) was made. Cytogenetic studies showed 45,X, t(8; 21), 5q-, -Y We report this case because, development of acute leukemia after LCH is rare and the literature searched for any cytogenetic study in these kind of cases yielded no data. |
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Authors:
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Vahap Aslan; O Meltem Akay; Beyhan Durak; Sare Kabukcuoglu; Zafer Gulbas |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 43 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-10-28 Completed Date: 2003-03-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
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Languages: eng Pagination: 1683-5 Citation Subset: IM |
Affiliation:
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Department of Hematology, Osmangazi University, Medical School, Eskisehir, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chromosomes, Human, Pair 21* Chromosomes, Human, Pair 8* Histiocytosis, Langerhans-Cell / complications, genetics* Humans Karyotyping Leukemia, Myeloid, Acute / etiology* Male Translocation, Genetic* |
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