Document Detail

Langerhans cell histiocytosis with transformation to acute leukemia showing 45,X, t(8; 21), 5q-, -Y karyotype.
MedLine Citation:
PMID:  12400613     Owner:  NLM     Status:  MEDLINE    
A 31 -year-old man was admitted to hospital with onset of difficulty in walking and urinary incontinence, leading to the diagnosis of Langerhans cell histiocytosis (LCH) which was replacing a thoracic vertebra. Four months after the completion of radiation therapy, he was referred to our department with persistent fever and severe pyogenic ulceration mainly affecting the right-hip. A diagnosis of acute non-lymphoblastic leukemia (ANLL) was made. Cytogenetic studies showed 45,X, t(8; 21), 5q-, -Y We report this case because, development of acute leukemia after LCH is rare and the literature searched for any cytogenetic study in these kind of cases yielded no data.
Vahap Aslan; O Meltem Akay; Beyhan Durak; Sare Kabukcuoglu; Zafer Gulbas
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  43     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-28     Completed Date:  2003-03-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  1683-5     Citation Subset:  IM    
Department of Hematology, Osmangazi University, Medical School, Eskisehir, Turkey.
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MeSH Terms
Chromosomes, Human, Pair 21*
Chromosomes, Human, Pair 8*
Histiocytosis, Langerhans-Cell / complications,  genetics*
Leukemia, Myeloid, Acute / etiology*
Translocation, Genetic*

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