Document Detail

Langerhans cell histiocytosis presenting as a limbal nodule in an adult patient.
MedLine Citation:
PMID:  15364252     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report a case of Langerhans cell histiocytosis presenting as a limbal nodule. DESIGN: Observational case report. METHOD: A 26-year-old man presented with a superior limbal mass. On clinical examination, an infiltrative/neoplastic lesion was suspected, and a differential diagnosis of limbal amyloidosis, limbal fibrous histiocytoma, lymphoma, and juvenile xanthogranuloma was made. There was no other associated ocular or systemic abnormality. An excision biopsy was performed. RESULTS: The histopathology and immunohistochemical staining examination established the diagnosis of limbal Langerhans cell histiocytosis. CONCLUSION: To the best of our knowledge, this is an unusual presentation of Langerhans cell histiocytosis, and although rare, Langerhans cell histiocytosis should be included in the differential diagnosis of a limbal mass.
Tishu Saxena; Krishna Kumar; Seema Sen; Radhika Tandon
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  138     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-14     Completed Date:  2004-10-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  508-10     Citation Subset:  AIM; IM    
Cornea and Refractive Surgery Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.
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MeSH Terms
Biological Markers / analysis
Corneal Diseases / diagnosis*,  metabolism
Diagnosis, Differential
Histiocytosis, Langerhans-Cell / diagnosis*,  metabolism
Limbus Corneae / metabolism,  pathology*
S100 Proteins / metabolism
Reg. No./Substance:
0/Biological Markers; 0/S100 Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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