Document Detail

Langerhans cell histiocytosis involving epiphysis of a long bone.
MedLine Citation:
PMID:  15060887     Owner:  NLM     Status:  MEDLINE    
Eosinophilic granulomas of long tubular bones, a form of Langerhans cell histiocytosis, occurs in metaphyses and diaphyses with equal frequency. Epiphyseal location is unusual, with only 13 cases previously reported in the literature. The present case involves the epiphysis of the upper end of the left femur in a 12-year-old boy with pain and limp in the affected area. Radiographic findings were an oval, radiolucent rarefaction with nonsclerotic border, measuring approximately 3.5 x 3.0 cm. Microscopic examination identified aggregates of histiocytes, multinucleated giant cells, scattered eosinophils, and few plasma cells and lymphocytes. Ultrastructural studies demonstrated Birbeck granules within cytoplasm of histiocytes diagnostic of Langerhans cell histiocytosis. Whether Langerhans cell histiocytosis is a neoplastic disorder or a reactive process remains controversial. The true nature of the Langerhans cell, the proliferating cells and hallmark of this disease, is likewise under scrutiny.
Romeo L Caballes; Romeo A Caballes; John J McKeon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of diagnostic pathology     Volume:  8     ISSN:  1092-9134     ISO Abbreviation:  Ann Diagn Pathol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-02     Completed Date:  2004-11-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9800503     Medline TA:  Ann Diagn Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM    
Departments of Pathology and Laboratory Medicine, and Orthopedic Surgery, University of Medicine & Dentistry of New Jersey-New Jersey Medical School, Newark, and Department of Internal Medicine, Hunterdon Medical Center, Flemington, NJ, USA.
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MeSH Terms
Epiphyses / pathology*,  radiography*,  ultrastructure
Femur / pathology*,  radiography*,  ultrastructure
Histiocytosis, Langerhans-Cell / pathology*,  radiography*

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